Question 1

Which of the following are intermediates in the acid hydrolysis of an amide?

Accepted Answer

A)   1
B)   2
C)   2 & 3
D)   4
E)   1, 2, & 3

Question 2

What are the products from the reaction of excess methyl magnesium bromide with ethyl acetate followed by H3O+?

Accepted Answer

t-butanol ...

Question 3

Predict the major product of the following reaction.

Accepted Answer

The answer of Predict the major product of the following...

Question 4

Cyclic amides are called ________.

Accepted Answer

A)   lactones
B)   lactams
C)   aminals
D)   animals
E)   imines

Question 5

Predict the major product of the following reaction.

Accepted Answer

The answer of Predict the major product of the following...

Question 6

Starting from methylpropane, how could you make methyl isobutyrate?

Accepted Answer

1) Cl₂, light
2) NaOH (S_N2 condi...

Question 7

Provide the major organic product of the following reaction.

Accepted Answer

The answer of Provide the major organic product of the...

Question 8

Using 1H NMR, how would you tell the two esters apart?

Accepted Answer

In the spectrum of the first e...

Question 9

Predict the major organic product from the following reaction.

Accepted Answer

A)   carboxylic acid
B)   ester
C)   nitrile
D)   2° amide

Question 10

List the following five compounds, ethanamide, 1-propanol, methyl formate, acetic acid, and propanenitrile, in order of increasing boiling point. Start with the lowest boiling compound.

Accepted Answer

methyl formate < pro...

Question 11

A nitrile can be made by dehydrating an amide. However, for this reaction to occur, the amide must be ________.

Accepted Answer

A)   primary
B)   secondary
C)   tertiary
D)   N-methylated
E)   part of a lactam

Question 12

Provide the IUPAC name for HCONHCH2CH2CH3.

Accepted Answer

Question 13

Distamycin and derivatives have exhibited antiviral, antibiotic, and antitumor activity by binding to the minor groove of DNA (J. Med. Chem. 2004, 2133). Place a line through each bond of distamycin that would be cleaved by acid hydrolysis.

Accepted Answer

The answer of Distamycin and derivatives have exhibited antiviral, antibiotic,...

Question 14

Draw the product resulting from the following reaction. Indicate any relevant stereochemistry.

Accepted Answer

The answer of Draw the product resulting from the following...

Question 15

What is the common name for the following carboxylic acid derivative?

Accepted Answer

A)   β-hydroxybutyronitrile
B)   1-cyano-2-butanol
C)   β-hydroxyvaleronitrile
D)   γ-hydroxyvaleronitrile
E)   2-hydroxypentane nitrile

Question 16

Predict the major organic product of the following reaction:

Accepted Answer

The answer of Predict the major organic product of the...

Question 17

Provide a detailed, stepwise mechanism for the reaction of propanoic anhydride with phenol.

Accepted Answer

The answer of Provide a detailed, stepwise mechanism for the...

Question 18

Shown below is the structure of Lactimidomycin, a potent inhibitor of cell migration, proliferation and protein synthesis. Identify the carboxylic acid derivative/s in the structure of Lactimidomycin.

Accepted Answer

A)   Ester
B)   Anhydride
C)   Nitrile
D)   Imine

Question 19

Arrange the carboxylic acid derivatives below in order of increasing reactivity towards nucleophilic acyl substitution.

Accepted Answer

A)   1 
B)   1 
C)   2 
D)   2 
E)   3 < 2 < 1

Question 20

Predict the major product of the following reaction.

Accepted Answer

The answer of Predict the major product of the following...

Exam 21: Carboxylic Acid Derivatives

Provide a detailed, stepwise mechanism for the reaction of propanoic anhydride with phenol.

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Distamycin and derivatives have exhibited antiviral, antibiotic, and antitumor activity by binding to the minor groove of DNA (J. Med. Chem. 2004, 2133). Place a line through each bond of distamycin that would be cleaved by acid hydrolysis.

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Arrange the carboxylic acid derivatives below in order of increasing reactivity towards nucleophilic acyl substitution.

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A nitrile can be made by dehydrating an amide. However, for this reaction to occur, the amide must be ________.

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Predict the major organic product from the following reaction.

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Using 1H NMR, how would you tell the two esters apart?

Correct AnswerverifiedIn the spectrum of the first e...View AnswerShow Answer

Predict the major product of the following reaction.

Correct AnswerverifiedShow Answer

Predict the major product of the following reaction.

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What is the common name for the following carboxylic acid derivative?

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Draw the product resulting from the following reaction. Indicate any relevant stereochemistry.

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Shown below is the structure of Lactimidomycin, a potent inhibitor of cell migration, proliferation and protein synthesis. Identify the carboxylic acid derivative/s in the structure of Lactimidomycin.

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Provide the IUPAC name for HCONHCH2CH2CH3.

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Which of the following are intermediates in the acid hydrolysis of an amide?

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Starting from methylpropane, how could you make methyl isobutyrate?

Correct Answerverified1) Cl2, light2) NaOH (SN2 condi...View AnswerShow Answer

Cyclic amides are called ________.

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Predict the major organic product of the following reaction:

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Provide the major organic product of the following reaction.

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List the following five compounds, ethanamide, 1-propanol, methyl formate, acetic acid, and propanenitrile, in order of increasing boiling point. Start with the lowest boiling compound.

Correct Answerverifiedmethyl formate < pro...View AnswerShow Answer

What are the products from the reaction of excess methyl magnesium bromide with ethyl acetate followed by H3O+?

Correct Answerverifiedt-butanol ...View AnswerShow Answer

Predict the major product of the following reaction.

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Using ¹H NMR, how would you tell the two esters apart?

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In the spectrum of the first e...
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Provide the IUPAC name for HCONHCH₂CH₂CH₃.

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1) Cl₂, light
2) NaOH (S_N2 condi...
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methyl formate < pro...
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What are the products from the reaction of excess methyl magnesium bromide with ethyl acetate followed by H₃O⁺?

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t-butanol ...
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