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IgG antibodies have a variety of mechanisms for acting on antigens.

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You step on something in the yard and get a puncture wound that does not bleed freely. Antigens from any microbes that entered the wound will most likely end up in the


A) appendix.
B) lymph nodes of the groin.
C) lymph nodes of the neck (cervical) .
D) lymph nodes of the armpit (axilla) .
E) spleen.

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Which of the following recognizes and binds to MHC II antigens and helps stabilize the binding of antigenic determinants to T cell receptors?


A) CCR3
B) MHC I
C) CD26
D) CD4
E) CCR5

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Which of the following statements about lymphocytes is FALSE?


A) Once they are mature, they migrate to secondary lymphoid organs.
B) B and T lymphocytes can be differentiated under the microscope.
C) Lymphocytes have integral surface glycoproteins by which they can be recognized.
D) The glycoproteins on the surface of a lymphocyte are designated with the prefix CD, for "cluster of differentiation."
E) Lymphocytes have different types of CD molecules in their cytoplasmic membranes.

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The protozoan that causes malaria is an intracellular parasite of red blood cells (RBCs) . An adaptive immune response to this parasite is problematic because


A) red blood cells do not produce MHC and therefore do not display the fact that they have been infected by presenting antigen.
B) the parasite damages leukocytes along with RBCs.
C) RBCs normally produce cytokines necessary for adaptive immune response, which this infection prevents.
D) complement cannot effectively destroy RBCs.
E) RBCs never enter lymphoid tissue.

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Cytokines are soluble regulatory proteins that act as intercellular signals and include substances such as interleukins, interferon, and growth factors.

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A single B lymphocyte can recognize multiple antigenic determinants.

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Which of the following statements regarding antibody function is FALSE?


A) They can prevent virus attachment to host cells.
B) They can facilitate phagocyte attack on bacteria with a capsule (glycocalyx) .
C) They can penetrate host cells to bind intracellular antigens.
D) They can facilitate cytotoxic attack by natural killer lymphocytes.
E) They can bind more than one pathogen at a time, forming large aggregates.

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C

Secretory IgA antibodies are unique because they


A) have unique light chains.
B) are Y-shaped molecules.
C) are present in the plasma.
D) are connected with J chains and short polypeptides to form dimers.
E) are present in lymph nodes.

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Which of the following statements about helper T cells is FALSE?


A) They secrete messenger proteins called cytokines.
B) They are sometimes called T4 cells.
C) There are two types: Th1 and Th2.
D) They cannot be distinguished from other T lymphocytes.
E) They function in conjunction with B cells.

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A natural killer lymphocyte detects the Fc region of an antibody bound to a cell and responds by releasing __________ and granzyme.

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perforin

Which of the following statements concerning specific immunity is FALSE?


A) It is the third line of defense.
B) It has memory.
C) It changes little with repeated exposure to the same pathogen.
D) It is acquired.
E) It is the body's ability to respond to specific invading pathogens.

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Class II MHC (major histocompatibility antigens) are found on


A) the skin.
B) red blood cells.
C) cytoplasmic membranes of nucleated cells.
D) muscle.
E) professional antigen-presenting cells.

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Which of the following statements concerning plasma cells is FALSE?


A) They live a long time and function as memory cells.
B) They are activated B cells.
C) They produce 2000 antibodies per second.
D) They secrete antibody molecules with antigen-determining sites that act only against specific antigen determinants.
E) The antibodies they produce can remain in circulation for years.

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Which of the following is true of interferons?


A) They are produced by virally infected cells.
B) They are involved in B lymphocyte activation and differentiation.
C) They are involved in chemotaxis of leukocytes.
D) They are substances used to signal between leukocytes.
E) They cause basophils and eosinophils to degranulate.

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The designation "B" for B lymphocytes comes from the


A) fact that these cells produce antibodies.
B) bone marrow where these cells mature.
C) fact that these cells are most abundant in the blood..
D) ability of these cells to provide immunity through bodily fluids.
E) sequence in which these lymphocytes where discovered.

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B

Describe the mechanisms of action of antibodies.

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Antibodies act against foreign antigens ...

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Which of the following function in agglutination?


A) IgA antibodies
B) IgG antibodies
C) IgE antibodies
D) IgD antibodies
E) IgA and IgG antibodies

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Compare and contrast clonal deletion and clonal selection of B lymphocytes.

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Both clonal deletion and clonal selectio...

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Which of the following molecules would contain T-independent antigens?


A) phospholipids
B) lipoproteins
C) polysaccharides
D) glycoproteins
E) steroids

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