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In the digestive system, some protease enzymes must be secreted as an inactive form and then activated later by proteolytic cleavage once outside of the secreting cell to prevent active proteases from damaging the secreting cells.What is the category of precursor proteins of this type?


A) ubiquitins
B) zymogens
C) glycosides
D) activins

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The genetic code includes


A) 3 start codons and 1 stop codon.
B) 2 start codons and 2 stop codons.
C) 1 start codon and 3 stop codons.
D) 0 start codons and 4 stop codons.

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The different tRNAs are produced by


A) different aminoacyl-tRNA synthetases that produce tRNAs from ribonucleotides in the cytoplasm.
B) RNA editing of transcripts of a single tRNA gene.
C) alternatively spliced of a single tRNA gene.
D) transcription of different tRNA genes in the genome.

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A mutation that occurs when a base is inserted into or deleted from a DNA sequence, completely altering the subsequent sequence of codons, is a


A) frameshift mutation.
B) missense mutation.
C) silent mutation.
D) nonsense mutation.

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Mutations that result in the production of much less of a protein or a protein that functions less efficiently than wild type are


A) null mutations.
B) hypomorphic mutations.
C) hypermorphic mutations.
D) conditional mutations.
E) neomorphic mutations.

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Mutations that completely abolish the function of a wild-type allele are


A) null mutations.
B) hypomorphic mutations.
C) hypermorphic mutations.
D) conditional mutations.
E) neomorphic mutations.

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Which enzyme forms peptide bonds between adjacent amino acids during polypeptide synthesis?


A) RNA polymerase
B) phosphotransferase
C) peptidyl transferase
D) ribonuclease

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A neomorphic mutation could result in an allele that


A) produces no gene product.
B) produces a nonfunctional gene product.
C) produces a novel protein that gives rise to a new phenotype.
D) produces mutant protein subunits that aggregate with wild-type subunits, inactivating them.
E) produces an altered protein that functions more efficiently than the wild-type protein does.

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Aminoacyl-tRNA synthetase is the enzyme that


A) folds tRNA molecules into their proper configuration.
B) causes tRNA molecules to bind to the aminoacyl site of a ribosome.
C) produces tRNA by reading DNA molecules.
D) adds the appropriate amino acid to an uncharged tRNA.

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A neomorphic mutation in the Antennapedia (Antp) gene of Drosophila causes


A) kinks to form in their tails.
B) growth of antenna from the leg region.
C) total loss of color vision.
D) extra antenna on the head.
E) growth of a leg from the head region.

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RNA polymerase binds to ________ before beginning transcription.


A) a promoter
B) an operator
C) a structural gene
D) a replication origin
E) the Shine-Dalgarno

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Which of these processes are coupled in prokaryotes but NOT in eukaryotes?


A) transcription and translation
B) replication and transcription
C) replication and translation
D) transcription and splicing

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Which of the following is required for initiation of eukaryotic translation?


A) Shine-Dalgarno sequence
B) 5' cap
C) release factors
D) N-formylmethionine
E) introns

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In the modification of eukaryotic mRNA, ________ cap and ________ tail are usually added to the transcript.


A) an acetylated-guanine; a poly-cytosine
B) a poly-guanine; a methyl group
C) a poly-thymine; an acetyl group
D) a methylated-guanine; a poly-adenine
E) a methylated-adenine; a poly-guanine

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A complex of proteins and small nuclear RNAs that form discrete particles to mediate splicing is a


A) holoenzyme.
B) spliceosome.
C) nucleosome.
D) ribosome.
E) chromosome.

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Drugs like AZT, ddC, or ddI work against the AIDS virus because they


A) destroy viral proteins.
B) look like hairpins to cause premature termination of viral mRNA.
C) look like tRNAs and block viral translation.
D) look like nitrogenous bases and block viral reverse transcriptase.
E) prevent the virus from releasing its genome into the cytoplasm.

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The DNA sequence 5' ATGCCTGAATCAGCTTTA 3' could encode a maximum of ____ amino acids in a protein.


A) 5
B) 6
C) 7
D) 18

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Select the statement that describes the stability of DNA and RNA under typical cellular conditions.


A) Double-stranded DNA in the nucleus and single-stranded RNA in the cytoplasm are equally stable.
B) Double-stranded DNA in the nucleus is more stable than single-stranded RNA in the cytoplasm.
C) Single-stranded RNA in the cytoplasm is more stable than double-stranded DNA in the nucleus.
D) Both RNA in the cytoplasm and double-stranded DNA in the nucleus can never be degraded within a cell.

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