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An antigen produced by a pathogen while living inside a cell is known as an (auto- /endogenous/exogenous) antigen.

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During an infection with Listeria, an intracellular bacterium, APCs will present antigen on MHC II molecules.

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A sick child may have influenza or RSV. These virus infections have different treatment options, so the physician requests antibody titer tests. The results are as follows: anti- influenza antibodies are primarily IgM, and anti- RSV antibodies are all IgA and IgG. Which of the following is the most appropriate interpretation?


A) The results do not provide sufficient data to draw a conclusion.
B) The child currently has influenza and has previously been exposed to RSV.
C) The child has a current RSV infection and was previously exposed to influenza.
D) The child has concurrent influenza and RSV infections.
E) The child has neither influenza nor RSV.

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Which of the following is correct concerning interleukin 4 (IL- 4) ?


A) It stimulates phagocytes.
B) It is needed for B lymphocyte activation and differentiation.
C) It ensures production of enough leukocytes.
D) Virally infected cells produce it.
E) It is a chemotactic factor for leukocytes.

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Which of the following is the function of gamma interferon (INF- y) ?


A) activates and differentiates B lymphocytes
B) ensures production of enough leukocytes
C) activates complement
D) causes basophils and eosinophils to degranulate
E) stimulates phagocytes

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Which of the following statements about lymphocytes is FALSE?


A) The glycoproteins on the surface of a lymphocyte are designated with the prefix CD, for "cluster of differentiation."
B) Once they are mature, they migrate to secondary lymphoid organs.
C) B and T lymphocytes can be differentiated under the microscope.
D) Lymphocytes have different types of CD molecules in their cytoplasmic membranes.
E) Lymphocytes have integral surface proteins by which they can be recognized.

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  What will be the direct result of the interaction shown in this figure? (This interaction is occurring in a lymph node.)  A)  clonal deletion of a T lymphocyte B)  activation of a helper T lymphocyte C)  activation of a B lymphocyte D)  activation of a cytotoxic T lymphocyte E)  clonal deletion of a B lymphocyte What will be the direct result of the interaction shown in this figure? (This interaction is occurring in a lymph node.)


A) clonal deletion of a T lymphocyte
B) activation of a helper T lymphocyte
C) activation of a B lymphocyte
D) activation of a cytotoxic T lymphocyte
E) clonal deletion of a B lymphocyte

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Which of the following statements concerning specific immunity is FALSE?


A) It is the body's ability to respond to specific invading pathogens.
B) It is the third line of defense.
C) It is acquired.
D) It has memory.
E) It changes little with repeated exposure to the same pathogen.

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Large accumulations of unactivated self- tolerant lymphocytes conducting surveillance for specific antigenic determinants are found in


A) the MALT, lymph nodes, and thymus.
B) the MALT and lymph nodes.
C) the thymus.
D) the MALT.
E) lymph nodes.

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Vaccination triggers an immune response which produces immunity.


A) artificial passive
B) natural active
C) natural passive
D) artificial active
E) both active and passive

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Describe the mechanisms of action of antibodies.

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Antibodies act against foreign antigens ...

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The Fc portion of an antibody is formed by


A) the variable regions of the heavy chains.
B) one heavy chain.
C) portions of both of the heavy chains only.
D) the light chains only.
E) the variable regions of the light chains.

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B lymphocytes can bind directly to large antigens with repeating polysaccharide subunits, such as a bacterial capsule that has antigenic determinants known as T- independent (receptors/antigens).

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An APC presents antigen to an unactivated T lymphocyte on an MHC I molecule and secretes IL- 12 at the same time. As a result the T lymphocyte differentiates into a (Th1/Th2/Tr) lymphocyte.

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Which of the following is true of chemokines?


A) They are involved in B lymphocyte activation and differentiation.
B) They ensure production of enough leukocytes.
C) They are chemotactic factors for leukocytes.
D) They are substances used to signal between leukocytes.
E) They cause basophils and eosinophils to degranulate.

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The white blood cells primarily responsible for adaptive immunity are


A) macrophages and neutrophils.
B) neutrophils and dendritic cells.
C) NK lymphocytes and neutrophils.
D) macrophages and eosinophils.
E) B lymphocytes and T lymphocytes.

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A variety of molecular components of the adaptive immune system bind epitopes (antigenic determinants). Compare and contrast the binding of epitopes by antibody molecules, T cell receptors (TCRs), and MHC molecules, and describe the consequences of the different interactions.

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Antibody molecules produced by B lymphoc...

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The (constant/end/variable) regions from the light and heavy chains of an antibody combine to form antigen- binding sites.

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Which of the following statements concerning plasma cells is TRUE?


A) They live for many years and function as memory cells.
B) They are descended from activated T cells.
C) They secrete a variety of antibody molecules specific for multiple epitopes.
D) The antibodies they produce can remain in circulation for years.
E) They can produce large quantities of antibodies on a daily basis.

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Professional antigen- presenting cells (APCs) include B cells, macrophages, and (dendritic/plasma/T) cells.

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