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The membrane potential of a cell is determined exclusively by that cell's sodium and potassium permeability.

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Excitatory graded potentials are those where the stimulus initiates a hyperpolarization of the cell.

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Saxitoxin (STX) is the most well -known paralytic shellfish toxin caused by the phenomenon known as "red tide." Which statement below best describes why this neurotoxin causes paralysis?


A) It acts by blocking voltage -gated sodium channels which are needed to generate an action potential.
B) It acts on the hypothalamus of the brain, shutting down all neurological functions.
C) It prevents the synaptic vesicles from migrating to the axon terminal; therefore, no action potentials are generated.
D) It blocks ligand -gated channels on the postsynaptic membrane, which blocks signals leaving the central nervous system.
E) It acts on the potassium channels within a neuron, hyperpolarizing the cell membrane; therefore, no action potential can be generated.

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Both activation and inactivation gates of a sodium channel are stimulated at the same time by a depolarization with the inactivation gate acting more slowly than the activation gate, thereby allowing sodium to enter the cell.

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At the resting membrane potential, the membrane is most permeable to________ , which moves_______the cell due to its electrochemical gradient.


A) chloride : into
B) potassium : into
C) sodium : out of
D) sodium : into
E) potassium : out of

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  -Identify the type of summation that is occurring in Figure 7.1 where  S  refers to a stimulus from one source measured in the postsynaptic membrane. A)  spatial B)  multiplier C)  temporal D)  suprathreshold E)  subthreshold -Identify the type of summation that is occurring in Figure 7.1 where "S" refers to a stimulus from one source measured in the postsynaptic membrane.


A) spatial
B) multiplier
C) temporal
D) suprathreshold
E) subthreshold

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What nervous system is found in the intestinal tract?


A) afferent nervous system
B) somatic nervous system
C) efferent nervous system
D) enteric nervous system
E) central nervous system

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Which of the following potentials dissipate in size as the potential moves away from the site of initiation?


A) graded potentials
B) threshold potentials
C) action potentials
D) both graded potentials and action potentials
E) neither graded potentials nor action potentials

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If the soma of a neuron became more permeable to potassium, which statement below best describes the graded potential that would be generated in the soma?


A) Potassium would leave the cell, causing the membrane to hyperpolarize.
B) Potassium is a cation; therefore, it would cause an excitatory depolarization.
C) Potassium is an inhibitory second messenger; therefore, it would cause amplification of the graded potential.
D) Potassium would reach its equilibrium potential and the voltage inside the cell would not change.
E) Potassium would enter the cell, causing the membrane to depolarize and reach threshold.

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What is the most common neuronal cell type?


A) efferent neuron
B) pseudo -unipolar neuron
C) afferent neuron
D) bipolar neuron
E) interneuron

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During the rapid depolarization phase of an action potential, the plasma membrane is more permeable to which of the following ions?


A) sodium (Na+)
B) potassium (K+)
C) chloride (Cl -)
D) calcium (Ca++)
E) phosphate (PO4 -)

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Why do the distributions of sodium and potassium ions across the plasma membrane of neurons not change appreciably, even following hundreds of action potentials?


A) The movement of sodium and potassium ions that occurs during an action potential is countered by the passive movement of these ions during the repolarization phase.
B) The movement of sodium and potassium ions that occurs during an action potential is countered by the passive movement of these ions during the after -hyperpolarization.
C) The movement of sodium and potassium ions that occurs during an action potential is countered by counter -transport of potassium with sodium during rest.
D) The movement of sodium and potassium ions that occurs during an action potential is countered by the active transport of these ions by the Na+/K+ pump.
E) The movement of sodium and potassium ions that occurs during an action potential is countered by the passive leak of these ions when a neuron is at rest.

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The resting membrane potential is close to the equilibrium potential of which of the following ions?


A) sodium (Na+)
B) potassium (K+)
C) chloride (Cl -)
D) calcium (Ca++)
E) phosphate (PO4 -)

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Which type of glial cell provides the myelin sheath for many axons in the central nervous system?


A) astrocytes
B) oligodendrocytes
C) microglia
D) ependymal cells
E) Schwann cell

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During which of the following states are the majority of voltage -gated sodium channels closed and incapable of opening?


A) during the absolute refractory period
B) during the after -hyperpolarization
C) during depolarization
D) during the relative refractory period
E) at the resting membrane potential

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The Na+/K+ pump distributes three sodium ions to the outside of the membrane and two potassium ions to the inside of the membrane.

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What is the inverse of resistance?


A) flux
B) current
C) conductance
D) voltage
E) impedance

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Describe how an action potential, originating at the axon hillock, is propagated along the axon. Include those factors that can alter conduction velocity.

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As an action potential is generated at t...

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_________is the mechanism by which action potentials are propagated in unmyelinated axons.


A) The regenerative mechanism
B) The all -or -none principle
C) Temporal summation
D) Electrotonic conduction
E) After -hyperpolarization

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Amyotrophic lateral sclerosis (ALS), often referred to as "Lou Gehrig's Disease," is a progressive neurodegenerative disease that affects the efferent division, particularly the motor neurons, of the nervous system. People with ALS have normal bodily functions and their ability to think, form memories, and to detect sensations is all normal. However, the progressive nature of this disease can lead to total paralysis. Based on your knowledge of the different divisions of the nervous system and the functioning of neurons, explain the symptoms of ALS.

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The efferent division of the nervous sys...

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