Question 1

What enzyme has a role in repression of eukaryotic gene expression?

Accepted Answer

A)   histone methylase
B)   histone demethylase
C)   histone acetylase
D)   histone deacetylase
E)   None of the answers is correct.

Question 2

How do coactivators mediate expression?

Accepted Answer

A)   blocking RNA polymerase binding
B)   modifying chromatin structure
C)   inhibiting intron splicing
D)   binding to enhancers
E)   None of the answers is correct.

Question 3

What is the complex of protein subunits that acts as a bridge between transcription factors and RNA polymerase II?

Accepted Answer

A)   coactivator
B)   repressor
C)   attenuator
D)   mediator
E)   None of the answers is correct.

Question 4

Which of the following causes a decrease in transferrin receptor levels and an increase in ferritin levels?

Accepted Answer

A)   magnesium
B)   calcium
C)   iron
D)   potassium
E)   manganese C

Question 5

Bromodomains are part of complexes which

Accepted Answer

A)   bind proteins.
B)   remodel chromatin.
C)   alter ribosome binding.
D)   remodel chromatin and alter ribosome binding.
E)   All the answers are correct.

Question 6

What are the requirements for binding of the bromodomain to the transcriptional machinery?

Accepted Answer

The bromodomain is also known as the ace...

Question 7

Describe the regulatory activity of microRNAs.

Accepted Answer

MicroRNAs, or miRNAs, are regulatory RNA...

Question 8

Describe the arrangement of histones and associated DNA in a nucleosome.

Accepted Answer

Two copies of each of the four histone p...

Question 9

Enhancer sites are often located

Accepted Answer

A)   near the poly(
A)   tail site.
B)   within introns.
C)   at a distance from the transcription start site.
D)   immediately adjacent to the promoter.
E)   None of the answers is correct.

Question 10

What is the function of mediator in regulating transcription?

Accepted Answer

The activation domains of tran...

Question 11

Although there are many differences between prokaryotic and eukaryotic gene expression, in what significant way due to the common structure of DNA are they similar?

Accepted Answer

Specific DNA sequences are rec...

Question 12

Regions that contain far more methylated cytosine than others are called

Accepted Answer

A)   hypersensitive regions.
B)   CpG islands.
C)   TpG mutation sites.
D)   hypermethylation regions.
E)   None of the answers is correct.

Question 13

What is meant by combinatorial control of transcription in eukaryotes, and what is the advantage to this mechanism?

Accepted Answer

The basal transcription initiates transc...

Question 14

The existence of stable cell types is due to differences in _____.

Accepted Answer

A)   the genome
B)   the epigenome
C)   histone acetylase activity
D)   transposable elements
E)   None of the answers is correct. B

Question 15

Seventy percent of the cytosines in human DNA are modified by methylation specifically in _______________ sequences.

Accepted Answer

The answer of Seventy percent of the cytosines in human...

Question 16

Ferritin mRNA includes a 5′ stem-loop structure and binds a(n) _______________, which blocks the initiation of translation under low iron conditions.

Accepted Answer

IRE-bindin...

Question 17

Give examples of epigenomic changes resulting in different cell types.

Accepted Answer

Changes in the epigenome of a ...

Question 18

What is the complex of DNA and associated proteins in the eukaryotic cell?

Accepted Answer

A)   chromosome
B)   chromatid
C)   chromatin
D)   karyotype
E)   None of the answers is correct.

Question 19

The ______________ histone seals off the nucleosome at the location at which the linker DNA enters and leaves.

Accepted Answer

H1

Question 20

Describe the functions of the two domains of a typical eukaryotic transcription factor.

Accepted Answer

The DNA-binding domain identifies and bi...

Exam 32: The Control of Gene Expression in Eukaryotes

What enzyme has a role in repression of eukaryotic gene expression?

Correct AnswerverifiedShow Answer

How do coactivators mediate expression?

Correct AnswerverifiedShow Answer

What is the complex of protein subunits that acts as a bridge between transcription factors and RNA polymerase II?

Correct AnswerverifiedShow Answer

Which of the following causes a decrease in transferrin receptor levels and an increase in ferritin levels?

Correct AnswerverifiedC

Bromodomains are part of complexes which

Correct AnswerverifiedShow Answer

What are the requirements for binding of the bromodomain to the transcriptional machinery?

Correct AnswerverifiedThe bromodomain is also known as the ace...View AnswerShow Answer

Describe the regulatory activity of microRNAs.

Correct AnswerverifiedMicroRNAs, or miRNAs, are regulatory RNA...View AnswerShow Answer

Describe the arrangement of histones and associated DNA in a nucleosome.

Correct AnswerverifiedTwo copies of each of the four histone p...View AnswerShow Answer

Enhancer sites are often located

Correct AnswerverifiedShow Answer

What is the function of mediator in regulating transcription?

Correct AnswerverifiedThe activation domains of tran...View AnswerShow Answer

Although there are many differences between prokaryotic and eukaryotic gene expression, in what significant way due to the common structure of DNA are they similar?

Correct AnswerverifiedSpecific DNA sequences are rec...View AnswerShow Answer

Regions that contain far more methylated cytosine than others are called

Correct AnswerverifiedShow Answer

What is meant by combinatorial control of transcription in eukaryotes, and what is the advantage to this mechanism?

Correct AnswerverifiedThe basal transcription initiates transc...View AnswerShow Answer

The existence of stable cell types is due to differences in _____.

Correct AnswerverifiedB

Seventy percent of the cytosines in human DNA are modified by methylation specifically in _______________ sequences.

Correct AnswerverifiedShow Answer

Ferritin mRNA includes a 5′ stem-loop structure and binds a(n) _______________, which blocks the initiation of translation under low iron conditions.

Correct AnswerverifiedIRE-bindin...View AnswerShow Answer

Give examples of epigenomic changes resulting in different cell types.

Correct AnswerverifiedChanges in the epigenome of a ...View AnswerShow Answer

What is the complex of DNA and associated proteins in the eukaryotic cell?

Correct AnswerverifiedShow Answer

The ______________ histone seals off the nucleosome at the location at which the linker DNA enters and leaves.

Correct AnswerverifiedH1

Describe the functions of the two domains of a typical eukaryotic transcription factor.

Correct AnswerverifiedThe DNA-binding domain identifies and bi...View AnswerShow Answer

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified
C

Correct Answer
verified

Correct Answer
verified
The bromodomain is also known as the ace...
View Answer

Correct Answer
verified
MicroRNAs, or miRNAs, are regulatory RNA...
View Answer

Correct Answer
verified
Two copies of each of the four histone p...
View Answer

Correct Answer
verified

Correct Answer
verified
The activation domains of tran...
View Answer

Correct Answer
verified
Specific DNA sequences are rec...
View Answer

Correct Answer
verified

Correct Answer
verified
The basal transcription initiates transc...
View Answer

Correct Answer
verified
B

Correct Answer
verified

Correct Answer
verified
IRE-bindin...
View Answer

Correct Answer
verified
Changes in the epigenome of a ...
View Answer

Correct Answer
verified

Correct Answer
verified
H1

Correct Answer
verified
The DNA-binding domain identifies and bi...
View Answer