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Neurotransmitters affect postsynaptic cells by


A) initiating signal transduction pathways in the cells.
B) causing molecular changes in the cells.
C) affecting ion-channel proteins.
D) altering the permeability of the cells.
E) All of these options are correct.

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If you experimentally increase the concentration of Na⁺ outside a cell while maintaining other ion concentrations as they were,what would happen to the cell's membrane potential?


A) The membrane potential would decrease.
B) The membrane potential would increase.
C) The membrane potential would be unaffected.
D) The membrane potential depends on the thermodynamic potential.
E) The membrane potential depends on the concentration of K⁺

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What would probably happen if a long neuron had one continuous myelin sheath down the length of the axon with no nodes of Ranvier?


A) The action potential would be propagated nearly instantaneously to the synapse.
B) There would be no action potential generated at the axon hillock.
C) The signal would fade because it is not renewed by the opening of more sodium channels.
D) The action potential would be slower than normal for that length of axon.
E) The action potential would be more negative than normal.

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Use the following information to answer the next few questions. Over the course of a year,you notice that you are more frequently losing your balance,are unable to keep your train of thought,and occasionally have double vision.After visiting several specialists,you are diagnosed with multiple sclerosis (MS) ,the hardening and ultimate loss of the myelin sheath which insulates axons. -The onset of these symptoms follows the loss of the myelin sheath,leading to


A) a loss in conduction speed of action potentials
B) an increase in conduction speed of action potentials.
C) consistent depolarization at the nodes of Ranvier.
D) increased saltatory conduction.
E) an increased diameter of the axon.

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Which of the following will increase the speed of an action potential moving down an axon? I.larger diameter axons. II.lack of potassium ion channels. III.myelinated axons.


A) only III
B) only I and II
C) only II and III
D) only I and III
E) I, II, and III

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The "selectivity" of a particular ion channel refers to its


A) permitting passage by positive but not negative ions.
B) permitting passage by negative but not positive ions.
C) ability to change its size depending on the ion needing transport.
D) binding with only one type of neurotransmitter.
E) permitting passage only to a specific ion.

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Botulinum toxin inhibits the presynaptic release of acetylcholine.If inhibition occurs at a neuromuscular junction,then


A) the synaptic cleft will close.
B) muscle contraction will cease.
C) the post-synaptic cell will die.
D) muscles will spasm.
E) receptor ion channels will remain open.

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Ionotropic receptors are found at synapses operated via


A) ligand-gated ion channels.
B) second-messenger-gated ion channels.
C) electrical synapses.
D) inhibitory, but not excitatory, synapses.
E) excitatory, but not inhibitory, synapses.

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The observation that the acetylcholine released into the junction between a motor neuron and a skeletal muscle binds to a sodium channel and opens it is an example of


A) a voltage-gated sodium channel.
B) a voltage-gated potassium channel.
C) a ligand-gated sodium channel.
D) a second-messenger-gated sodium channel.
E) a chemical that inhibits action potentials.

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The "undershoot" phase of after-hyperpolarization is due to


A) slow opening of voltage-gated sodium channels.
B) sustained opening of voltage-gated potassium channels.
C) rapid opening of voltage-gated calcium channels.
D) slow restorative actions of the sodium-potassium ATPase.
E) ions that move away from their open ion channels.

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Which is the correct order for processing and integrating sensory stimuli?


A) stimuli → sensory neuron → sensory nerve → CNS → PNS
B) stimuli → sensory nerve → sensory neuron → PNS → CNS
C) stimuli → sensory neuron → sensory nerve → PNS → CNS
D) stimuli → sensory nerve → sensory neuron → CNS → PNS
E) sensory nerve → stimuli → sensory neuron → PNS → CNS

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Two fundamental concepts about the ion channels of a "resting" neuron are that the channels


A) are always open, but the concentration gradients of ions frequently change.
B) are always closed, but ions move closer to the channels during excitation.
C) open and close depending on stimuli, and are specific as to which ion can traverse them.
D) open and close depending on chemical messengers, and are nonspecific as to which ion can traverse them.
E) open in response to stimuli, and then close simultaneously, in unison.

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An amino acid that operates at inhibitory synapses in the brain is


A) acetylcholine.
B) epinephrine.
C) endorphin.
D) nitric oxide.
E) GABA.

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Which of the following ions is most likely to cross the plasma membrane of a resting neuron?


A) K⁺
B) Na⁺
C) Ca²⁺
D) Cl⁻
E) H₂O

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Which of the following statements about action potentials is correct?


A) Action potentials for a given neuron vary in magnitude.
B) Action potentials for a given neuron vary in duration.
C) Action potentials are propagated down the length of the axon.
D) Movement of ions during the action potential occurs mostly through the Na⁺ pump.
E) Action potentials of all cells are of the same speed.

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The operation of the sodium-potassium "pump" moves


A) sodium and potassium ions into the cell.
B) sodium and potassium ions out of the cell.
C) sodium ions into the cell and potassium ions out of the cell.
D) sodium ions out of the cell and potassium ions into the cell.
E) sodium and potassium ions into the mitochondria.

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In multiple sclerosis the myelin sheaths around the axons of the brain and spinal cord are damaged and demyelination results.How does this disease manifest at the level of the action potential? I.Action potentials move in the opposite direction on the axon. II.Action potentials move more slowly along the axon. III.No action potentials are transmitted.


A) only I
B) only II
C) only III
D) only II and III
E) I, II and III

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The heart rate decreases in response to the arrival of


A) acetylcholine.
B) epinephrine.
C) endorphin.
D) nitric oxide.
E) GABA.

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Saltatory conduction is a term applied to


A) conduction of impulses across electrical synapses.
B) an action potential that skips the axon hillock in moving from the dendritic region to the axon terminal.
C) rapid movement of an action potential reverberating back and forth along a neuron.
D) jumping from one neuron to an adjacent neuron.
E) jumping from one node of Ranvier to the next in a myelinated neuron.

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Neural transmission across a mammalian synaptic gap is accomplished by


A) the movement of sodium and potassium ions from the presynaptic neuron into the postsynaptic neuron.
B) impulses travelling as electrical currents across the gap.
C) impulses causing the release of a chemical signal and its diffusion across the gap.
D) impulses ricocheting back and forth across the gap.
E) the movement of calcium ions from the presynaptic into the postsynaptic neuron.

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