Question 1

Non-linear Pharmacokinetics also called as…………

Accepted Answer

A)  Mixed order
B)  Saturated kinetics
C)  Capacity Limited
D)  All of the aboveE) A) and D)
F) All of the above

Question 2

Active processes which are Saturable in renal excretion of drug includes…….

Accepted Answer

A)  Active tubular secretion
B)  Active tubular reabsorption
C)  Both of the above
D)  None of the aboveE) None of the above
F) All of the above

Question 3

………..it is the extent to which a drug will accumulate relative to the first dose can be quantified by an accumulation factor R.

Accepted Answer

A)  Accumulation Index
B)  Apparent volume of drug distribution
C)  Accumulation factor
D)  None of the aboveE) A) and B)
F) A) and C)

Question 4

Which of the following creates nonlinearity in drug distribution and not in drug absorption?

Accepted Answer

A)  When absorption is solubility or dissolution rate-limited
B)  When absorption involves carrier-mediated transport systems
C)  When a presystemic gut wall or hepatic metabolism attains saturation
D)  Saturation of binding sites on plasma proteinsE) None of the above
F) A) and B)

Question 5

Name the different methods used to estimate Km and Vmax graphically.

Accepted Answer

A)  Direct Linear plot
B)  Lineweaver -Burke plot or Klotz Plot
C)  Graphical Method
D)  All of the aboveE) A) and B)
F) A) and C) D

Question 6

Which organ comprises the peripheral compartment in a two compartment model?

Accepted Answer

A)  Liver
B)  Lungs
C)  Kidneys
D)  MusclesE) A) and D)
F) None of the above

Question 7

In…………..Pharmacokinetic parameters for a drug can change with change in dose.

Accepted Answer

A)  Linear Pharmacokinetics
B)  Non-linear Pharmacokinetics
C)  Both of the above
D)  None of the aboveE) B) and D)
F) A) and B) B

Question 8

Which of the following is not a category of 2 compartment model?

Accepted Answer

A)  Two compartment model with elimination from the central compartment
B)  Two compartment model with elimination from the peripheral compartment
C)  Two compartment model with elimination from only plasma and blood
D)  Two compartment model with elimination from both the compartmentsE) A) and B)
F) None of the above

Question 9

If the steady-state plasma concentration is directly proportional to the dose, then ……….in the kinetics exists.

Accepted Answer

A)  Linearity
B)  Non-linearity
C)  Both of the above
D)  None of the aboveE) All of the above
F) B) and C)

Question 10

Which of following drug shows non-linearity in hepatic excretion?

Accepted Answer

A)  Carbamazepine
B)  Propranolol
C)  Penicillin
D)  ThiopentalE) A) and B)
F) A) and C)

Question 11

Linear Pharmacokinetics is………………

Accepted Answer

A)  Dose dependent
B)  Dose independent
C)  Both of the above
D)  None of the aboveE) None of the above
F) All of the above A

Question 12

Linear Pharmacokinetics also referred as………….

Accepted Answer

A)  First-order kinetics
B)  Second order kinetics
C)  Pseudo order kinetics
D)  None of the above inE) A) and D)
F) None of the above

Question 13

Pharmacokinetics parameters change as per………… of dose administered?

Accepted Answer

A)  Size
B)  Route
C)  Both of free above
D)  None of the aboveE) B) and D)
F) None of the above

Question 14

The………………….. is common cause of both dose and time dependent kinetics

Accepted Answer

A)  Capacity limited Process
B)  Dose volume
C)  Enzyme induction
D)  None of the aboveE) A) and B)
F) None of the above

Question 15

In Michaelis-Menton Equation, When the value of Km = C

Accepted Answer

A)  rate of process is half (1 /2)  the maximum rate.
B)  the elimination of most drugs follows first order kinetic
C)  the elimination of most drugs follows zero order kinetic
D)  the elimination of most drugs follows second order kineticE) None of the above
F) A) and B)

Question 16

Which of the following is correct statement about Nonlinear pharmacokinetics?

Accepted Answer

A)  The pharmacokinetic parameters of a drug will not change when multiple doses of drug are administered
B)  The graph of the relationship between the different factors involved (dose, blood plasma concentrations, elimination, etc.)  gives a straight line.
C)  the plasma drug concentration changes either more or less than would be expected from a change in dose rate.
D)  None of the aboveE) None of the above
F) A) and B)

Question 17

Which of the following Factors causing Non-linearity?

Accepted Answer

A)  Nonlinearity may arise due to pathological alteration at any one of the various pharmacokinetic steps, such as absorption, distribution and/or elimination.
B)  Nonlinearity may arise due to Capacity-limited metabolism.
C)  Nonlinearity may arise due to alteration in protein binding characteristics
D)  All of the aboveE) All of the above
F) C) and D)

Question 18

Any changes in fraction bioavailable, elimination half-life indicates nonlinearity of that particular drug.

Accepted Answer

A)  True
B)  False
C)  none
D)  allE) None of the above
F) All of the above

Question 19

Which one of these is correct Michaelis-Menten equation?

Accepted Answer

A)  -dC/dt = Vmax C/Km+C
B)  dC/dt = Vmax C/Km+C
C)  -dC/dt = Vmax C/Km
D)  -dC/dt = Km+C / Vmax CE) None of the above
F) C) and D)

Question 20

Non-linear pharmacokinetics is also known as………

Accepted Answer

A)  dose dependent
B)  enzyme capacity limited
C)  saturation pharmacokinetics
D)  All of the aboveE) A) and B)
F) A) and C)

Exam 24: Pharmacokinetics and Nonlinear Pharmacokinetics: Understanding Drug Kinetics and Dose-Dependent Effects

Non-linear Pharmacokinetics also called as…………

Correct AnswerverifiedShow Answer

Active processes which are Saturable in renal excretion of drug includes…….

Correct AnswerverifiedShow Answer

………..it is the extent to which a drug will accumulate relative to the first dose can be quantified by an accumulation factor R.

Correct AnswerverifiedShow Answer

Which of the following creates nonlinearity in drug distribution and not in drug absorption?

Correct AnswerverifiedShow Answer

Name the different methods used to estimate Km and Vmax graphically.

Correct AnswerverifiedD

Which organ comprises the peripheral compartment in a two compartment model?

Correct AnswerverifiedShow Answer

In…………..Pharmacokinetic parameters for a drug can change with change in dose.

Correct AnswerverifiedB

Which of the following is not a category of 2 compartment model?

Correct AnswerverifiedShow Answer

If the steady-state plasma concentration is directly proportional to the dose, then ……….in the kinetics exists.

Correct AnswerverifiedShow Answer

Which of following drug shows non-linearity in hepatic excretion?

Correct AnswerverifiedShow Answer

Linear Pharmacokinetics is………………

Correct AnswerverifiedA

Linear Pharmacokinetics also referred as………….

Correct AnswerverifiedShow Answer

Pharmacokinetics parameters change as per………… of dose administered?

Correct AnswerverifiedShow Answer

The………………….. is common cause of both dose and time dependent kinetics

Correct AnswerverifiedShow Answer

In Michaelis-Menton Equation, When the value of Km = C

Correct AnswerverifiedShow Answer

Which of the following is correct statement about Nonlinear pharmacokinetics?

Correct AnswerverifiedShow Answer

Which of the following Factors causing Non-linearity?

Correct AnswerverifiedShow Answer

Any changes in fraction bioavailable, elimination half-life indicates nonlinearity of that particular drug.

Correct AnswerverifiedShow Answer

Which one of these is correct Michaelis-Menten equation?

Correct AnswerverifiedShow Answer

Non-linear pharmacokinetics is also known as………

Correct AnswerverifiedShow Answer

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified
D

Correct Answer
verified

Correct Answer
verified
B

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified
A

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified