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A particular cell has half as much DNA as some other cells in a mitotically active tissue. The cell in question is most likely in


A) G₁
B) G₂.
C) prophase.
D) metaphase.
E) anaphase.

F) B) and C)
G) A) and E)

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Cells that are in a nondividing state are in which phase?


A) G₀
B) G₂
C) G₁
D) S
E) M

F) All of the above
G) A) and E)

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Which of the following best describes how chromosomes move toward the poles of the spindle during mitosis?


A) The chromosomes are "reeled in" by the contraction of spindle microtubules.
B) Motor proteins of the kinetochores move the chromosomes along the spindle microtubules.
C) Non-kinetochore spindle fibers serve to push chromosomes in the direction of the poles.
D) both A and B
E) A, B, and C

F) A) and E)
G) D) and E)

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Figure 12.2 Figure 12.2   -If there are 20 chromatids in a cell at metaphase, how many chromosomes are there in each daughter cell following cytokinesis? A) 10 B) 20 C) 30 D) 40 E) 80 -If there are 20 chromatids in a cell at metaphase, how many chromosomes are there in each daughter cell following cytokinesis?


A) 10
B) 20
C) 30
D) 40
E) 80

F) A) and D)
G) B) and D)

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Which of the following describe(s) cyclin-dependent kinase (Cdk) ?


A) Cdk is inactive, or "turned off," in the presence of cyclin.
B) Cdk is present throughout the cell cycle.
C) Cdk is an enzyme that attaches phosphate groups to other proteins.
D) Both A and B are True.
E) Both B and C are True.

F) A) and E)
G) C) and D)

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Why do chromosomes coil during mitosis?


A) to increase their potential energy
B) to allow the chromosomes to move without becoming entangled and breaking
C) to allow the chromosomes to fit within the nuclear envelope
D) to allow the sister chromatids to remain attached
E) to provide for the structure of the centromere

F) C) and D)
G) A) and E)

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Use the following information to answer the questions below. The lettered circle in Figure 12.1 shows a diploid nucleus with four chromosomes. There are two pairs of homologous chromosomes, one long and the other short. One haploid set is symbolized as black and the other haploid set is gray. The chromosomes in the unlettered circle have not yet replicated. Choose the correct chromosomal conditions for the following stages. Use the following information to answer the questions below. The lettered circle in Figure 12.1 shows a diploid nucleus with four chromosomes. There are two pairs of homologous chromosomes, one long and the other short. One haploid set is symbolized as black and the other haploid set is gray. The chromosomes in the unlettered circle have not yet replicated. Choose the correct chromosomal conditions for the following stages.      -If cells in the process of dividing are subjected to colchicine, a drug that interferes with the functioning of the spindle apparatus, at which stage will mitosis be arrested? A) anaphase B) prophase C) telophase D) metaphase E) interphase -If cells in the process of dividing are subjected to colchicine, a drug that interferes with the functioning of the spindle apparatus, at which stage will mitosis be arrested?


A) anaphase
B) prophase
C) telophase
D) metaphase
E) interphase

F) A) and E)
G) B) and C)

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Density-dependent inhibition is explained by which of the following?


A) As cells become more numerous, they begin to squeeze against each other, restricting their size and ability to produce control factors.
B) As cells become more numerous, the cell surface proteins of one cell contact the adjoining cells and they stop dividing.
C) As cells become more numerous, the protein kinases they produce begin to compete with each other, such that the proteins produced by one cell essentially cancel those produced by its neighbor.
D) As cells become more numerous, more and more of them enter the S phase of the cell cycle.
E) As cells become more numerous, the level of waste products increases, eventually slowing down metabolism.

F) A) and C)
G) None of the above

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The research team used the setup to study the incorporation of labeled nucleotides into a culture of lymphocytes and found that the lymphocytes incorporated the labeled nucleotide at a significantly higher level after a pathogen was introduced into the culture. They concluded that


A) the presence of the pathogen made the experiment too contaminated to trust the results.
B) their tissue culture methods needed to be relearned.
C) infection causes lymphocytes to divide more rapidly.
D) infection causes cell cultures in general to reproduce more rapidly.
E) infection causes lymphocyte cultures to skip some parts of the cell cycle.

F) B) and D)
G) C) and D)

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Measurements of the amount of DNA per nucleus were taken on a large number of cells from a growing fungus. The measured DNA levels ranged from 3 to 6 picograms per nucleus. In which stage of the cell cycle was the nucleus with 6 picograms of DNA?


A) G₀
B) G₁
C) S
D) G₂
E) M

F) B) and D)
G) A) and D)

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Starting with a fertilized egg (zygote) , a series of five cell divisions would produce an early embryo with how many cells?


A) 4
B) 8
C) 16
D) 32
E) 64

F) A) and B)
G) C) and D)

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The formation of a cell plate is beginning across the middle of a cell and nuclei are re-forming at opposite ends of the cell. What kind of cell is this?


A) an animal cell in metaphase
B) an animal cell in telophase
C) an animal cell undergoing cytokinesis
D) a plant cell in metaphase
E) a plant cell undergoing cytokinesis

F) C) and D)
G) A) and B)

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Which of the following triggers the cell's passage past the G₂ checkpoint into mitosis?


A) PDGF
B) MPF
C) protein kinase
D) cyclin
E) Cdk

F) A) and B)
G) A) and C)

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A particular cyclin called cyclin E forms a complex with a cyclin-dependent kinase called Cdk 2. This complex is important for the progression of the cell from G₁ into the S phase of the cell cycle. Which of the following statements is correct?


A) The amount of cyclin E is greatest during the S phase.
B) The amount of Cdk 2 is greater during G₁ compared to the S phase.
C) The amount of cyclin E is highest during G₁.
D) The amount of Cdk 2 is greatest during G₁.
E) The activity of the cyclin E/Cdk 2 complex is highest during G₂.

F) A) and B)
G) A) and C)

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During which phases of mitosis are chromosomes composed of two chromatids?


A) from interphase through anaphase
B) from G₁ of interphase through metaphase
C) from metaphase through telophase
D) from anaphase through telophase
E) from G₂ of interphase through metaphase

F) A) and C)
G) None of the above

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Use the following information to answer the questions below. The lettered circle in Figure 12.1 shows a diploid nucleus with four chromosomes. There are two pairs of homologous chromosomes, one long and the other short. One haploid set is symbolized as black and the other haploid set is gray. The chromosomes in the unlettered circle have not yet replicated. Choose the correct chromosomal conditions for the following stages. Use the following information to answer the questions below. The lettered circle in Figure 12.1 shows a diploid nucleus with four chromosomes. There are two pairs of homologous chromosomes, one long and the other short. One haploid set is symbolized as black and the other haploid set is gray. The chromosomes in the unlettered circle have not yet replicated. Choose the correct chromosomal conditions for the following stages.      -A cell containing 92 chromatids at metaphase of mitosis would, at its completion, produce two nuclei each containing how many chromosomes? A) 12 B) 16 C) 23 D) 46 E) 92 -A cell containing 92 chromatids at metaphase of mitosis would, at its completion, produce two nuclei each containing how many chromosomes?


A) 12
B) 16
C) 23
D) 46
E) 92

F) A) and D)
G) C) and D)

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The following questions are based on Figure 12.3. The following questions are based on Figure 12.3.    -In the figure above, mitosis is represented by which number? A) I B) II C) III D) IV E) V -In the figure above, mitosis is represented by which number?


A) I
B) II
C) III
D) IV
E) V

F) B) and D)
G) A) and C)

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Which of the following is a protein synthesized at specific times during the cell cycle that associates with a kinase to form a catalytically active complex?


A) PDGF
B) MPF
C) protein kinase
D) cyclin
E) Cdk

F) B) and C)
G) All of the above

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Which of the following does not occur during mitosis?


A) condensation of the chromosomes
B) replication of the DNA
C) separation of sister chromatids
D) spindle formation
E) separation of the spindle poles

F) B) and D)
G) A) and B)

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Imagine looking through a microscope at a squashed onion root tip. The chromosomes of many of the cells are plainly visible. In some cells, replicated chromosomes are aligned along the center (equator) of the cell. These particular cells are in which stage of mitosis?


A) telophase
B) prophase
C) anaphase
D) metaphase
E) prometaphase

F) A) and C)
G) A) and D)

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