Question 1

Anemia in hypersplenism differs from anemia found in true hypoproliferative anemias because in hypersplenism,there is:

Accepted Answer

A)  Reticulocytosis
B)  Ineffective hematopoiesis
C)  Dyshematopoiesis
D)  Hypoplastic bone marrow

Question 2

Define constitutional aplastic anemia,and give an example.

Accepted Answer

Constitutional aplastic anemia...

Question 3

Which CDA is characterized by a positive Ham test and a negative sucrose lysis test?

Accepted Answer

A)  CDA I
B)  CDA II
C)  CDA III
D)  CDA IV

Question 4

What is a viable explanation as to why some individuals suffer stem cell damage when exposed to chemical agents but others do not?

Accepted Answer

A)  Longer life span of some red cells
B)  Superior detoxification
C)  Autoimmune disorders
D)  Lack of exposure

Question 5

Which of the following puts a patient taking chloramphenicol at risk for developing aplastic anemia?

Accepted Answer

A)  The drug promotes an immune response against stem cells.
B)  The drug is toxic to the bone marrow.
C)  The drug results in stem cell resistance to essential cytokines.
D)  The drug causes decreased cytokine production.

Question 6

Fanconi's syndrome is an example of:

Accepted Answer

A)  Constitutional aplastic anemia
B)  Acquired aplastic anemia
C)  Constitutional anemia from external stimuli
D)  Acquired aplastic anemia from external exposure

Question 7

The presence of what poikilocyte would lead to a suspicion of myelophthisic anemia rather than pure red cell aplasia?

Accepted Answer

A)  Dacryocyte
B)  Drepanocyte
C)  Schistocyte
D)  Stomatocyte A

Question 8

Diamond-Blackfan syndrome anemia is a rare congenital progressive erythrocyte aplasia.What is the most probable defect causing this rare disorder?

Accepted Answer

A)  Deficiency of erythropoietin
B)  Antibodies against erythropoietin
C)  Intrinsic defect of erythroid progenitor cells
D)  Increased reticulocytes

Question 9

Correlate the prognosis associated with the following treatments for aplastic anemia.
a.Bone marrow transplant
b.Cytokine therapy
c.Stem cell transplant
d.Immunosuppression therapy

Accepted Answer

a.Good prognosis
b.G...

Question 10

Aplastic anemia in the acquired form can result from drugs or chemical agent exposure.If the link cannot be made to any environmental factor,what form of anemia does the client have?

Accepted Answer

A)  Pure red cell aplasia
B)  Anemia of chronic renal disease
C)  Idiopathic
D)  Chronic

Question 11

Which of the following is among the diagnostic criteria for aplastic anemia?

Accepted Answer

A)  Granulocyte count > 0.5 x 10⁹/L
B)  Platelet count 
C)  Anemia
D)  Anemia with B

Question 12

Recent evidence suggests that the pathophysiology of most cases of acquired aplastic anemia is most likely:

Accepted Answer

A)  Drug exposure
B)  Viral infections
C)  Defective stem cells
D)  Immunologic suppression of hematopoiesis

Question 13

Aplastic anemia is usually first noted by bleeding and the presence of petechial hemorrhages.What clinical sign in the early stages of the disease should cause doubt on the diagnosis of aplastic anemia?

Accepted Answer

A)  Hepatosplenomegaly
B)  Splenomegaly
C)  Lymph node enlargement
D)  Fever

Question 14

Laboratory findings include a blood urea nitrogen >30 mg/dL,serum ferritin levels higher than normal,and a normocytic,normochromic morphology.What cause can be attributed to the anemia?

Accepted Answer

A)  Chronic renal disease
B)  Iron deficiency
C)  Diamond-Blackfan anemia
D)  Fanconi's syndrome

Question 15

Which of the following describes the bone marrow in a patient with Fanconi's syndrome?

Accepted Answer

A)  Hypercellular with erythroid hyperplasia
B)  Hypocellular with normal M:E ratio
C)  Normocellular with decreased M:E ratio
D)  Hypocellular with elevated M:E ratio

Question 16

Explain how exposure to the following can lead to aplastic anemia.
a.Chloramphenicol
b.Benzene
c.Gamma radiation
d.Starvation

Accepted Answer

a.Bone marrow toxicity
b.Toxicity to com...

Question 17

Hypoproliferative anemia is defined as:

Accepted Answer

A)  Decreased hematopoiesis in the bone marrow
B)  Decreased hematopoiesis in the liver
C)  Decreased erythropoiesis in the bone marrow
D)  Ineffective erythropoiesis in the bone marrow

Question 18

Which of the following treatments offers the best prognosis for aplastic anemia?

Accepted Answer

A)  Synthetic cytokines
B)  Bone marrow transplant
C)  Immunosuppressive therapy
D)  Stem cell transplant

Question 19

All of the following are considered diagnostic criteria for aplastic anemia except:

Accepted Answer

A)  
B)  
C)  
D)

Question 20

A 3-month-old infant is exhibiting pallor and fatigue.The pediatrician orders a CBC,which displays a low RBC count,H&H,and normal WBC and PLT counts.EPO levels are increased.BM aspirate shows prominent erythroid hypoplasia.Cytogenetic analysis reveals the presence of RPS19 mutation.Based on these findings,what is the patient most likely suffering from?

Accepted Answer

A)  CDA II
B)  Pure red cell aplasia
C)  Diamond-Blackfan anemia
D)  Fanconi's syndrome C

Exam 16: Hypoproliferative Anemias

Anemia in hypersplenism differs from anemia found in true hypoproliferative anemias because in hypersplenism,there is:

Correct Answer
verified

Define constitutional aplastic anemia,and give an example.

Correct Answer
verified
Constitutional aplastic anemia...
View Answer

Which CDA is characterized by a positive Ham test and a negative sucrose lysis test?

Correct Answer
verified

What is a viable explanation as to why some individuals suffer stem cell damage when exposed to chemical agents but others do not?

Correct Answer
verified

Which of the following puts a patient taking chloramphenicol at risk for developing aplastic anemia?

Correct Answer
verified

Fanconi's syndrome is an example of:

Correct Answer
verified

The presence of what poikilocyte would lead to a suspicion of myelophthisic anemia rather than pure red cell aplasia?

Correct Answer
verified
A

Diamond-Blackfan syndrome anemia is a rare congenital progressive erythrocyte aplasia.What is the most probable defect causing this rare disorder?

Correct Answer
verified

Correlate the prognosis associated with the following treatments for aplastic anemia. a.Bone marrow transplant b.Cytokine therapy c.Stem cell transplant d.Immunosuppression therapy

Correct Answer
verified
a.Good prognosis
b.G...
View Answer

Aplastic anemia in the acquired form can result from drugs or chemical agent exposure.If the link cannot be made to any environmental factor,what form of anemia does the client have?

Correct Answer
verified

Which of the following is among the diagnostic criteria for aplastic anemia?

Correct Answer
verified
B

Recent evidence suggests that the pathophysiology of most cases of acquired aplastic anemia is most likely:

Correct Answer
verified

Aplastic anemia is usually first noted by bleeding and the presence of petechial hemorrhages.What clinical sign in the early stages of the disease should cause doubt on the diagnosis of aplastic anemia?

Correct Answer
verified

Laboratory findings include a blood urea nitrogen >30 mg/dL,serum ferritin levels higher than normal,and a normocytic,normochromic morphology.What cause can be attributed to the anemia?

Correct Answer
verified

Which of the following describes the bone marrow in a patient with Fanconi's syndrome?

Correct Answer
verified

Explain how exposure to the following can lead to aplastic anemia. a.Chloramphenicol b.Benzene c.Gamma radiation d.Starvation

Correct Answer
verified
a.Bone marrow toxicity
b.Toxicity to com...
View Answer

Hypoproliferative anemia is defined as:

Correct Answer
verified

Which of the following treatments offers the best prognosis for aplastic anemia?

Correct Answer
verified

All of the following are considered diagnostic criteria for aplastic anemia except:

Correct Answer
verified

Correct Answer
verified
C

Exam 16: Hypoproliferative Anemias

Anemia in hypersplenism differs from anemia found in true hypoproliferative anemias because in hypersplenism,there is:

Correct AnswerverifiedShow Answer

Define constitutional aplastic anemia,and give an example.

Correct AnswerverifiedConstitutional aplastic anemia...View AnswerShow Answer

Which CDA is characterized by a positive Ham test and a negative sucrose lysis test?

Correct AnswerverifiedShow Answer

What is a viable explanation as to why some individuals suffer stem cell damage when exposed to chemical agents but others do not?

Correct AnswerverifiedShow Answer

Which of the following puts a patient taking chloramphenicol at risk for developing aplastic anemia?

Correct AnswerverifiedShow Answer

Fanconi's syndrome is an example of:

Correct AnswerverifiedShow Answer

The presence of what poikilocyte would lead to a suspicion of myelophthisic anemia rather than pure red cell aplasia?

Correct AnswerverifiedA

Diamond-Blackfan syndrome anemia is a rare congenital progressive erythrocyte aplasia.What is the most probable defect causing this rare disorder?

Correct AnswerverifiedShow Answer

Correlate the prognosis associated with the following treatments for aplastic anemia. a.Bone marrow transplant b.Cytokine therapy c.Stem cell transplant d.Immunosuppression therapy

Correct Answerverifieda.Good prognosisb.G...View AnswerShow Answer

Aplastic anemia in the acquired form can result from drugs or chemical agent exposure.If the link cannot be made to any environmental factor,what form of anemia does the client have?

Correct AnswerverifiedShow Answer

Which of the following is among the diagnostic criteria for aplastic anemia?

Correct AnswerverifiedB

Recent evidence suggests that the pathophysiology of most cases of acquired aplastic anemia is most likely:

Correct AnswerverifiedShow Answer

Aplastic anemia is usually first noted by bleeding and the presence of petechial hemorrhages.What clinical sign in the early stages of the disease should cause doubt on the diagnosis of aplastic anemia?

Correct AnswerverifiedShow Answer

Laboratory findings include a blood urea nitrogen >30 mg/dL,serum ferritin levels higher than normal,and a normocytic,normochromic morphology.What cause can be attributed to the anemia?

Correct AnswerverifiedShow Answer

Which of the following describes the bone marrow in a patient with Fanconi's syndrome?

Correct AnswerverifiedShow Answer

Explain how exposure to the following can lead to aplastic anemia. a.Chloramphenicol b.Benzene c.Gamma radiation d.Starvation

Correct Answerverifieda.Bone marrow toxicityb.Toxicity to com...View AnswerShow Answer

Hypoproliferative anemia is defined as:

Correct AnswerverifiedShow Answer

Which of the following treatments offers the best prognosis for aplastic anemia?

Correct AnswerverifiedShow Answer

All of the following are considered diagnostic criteria for aplastic anemia except:

Correct AnswerverifiedShow Answer

Correct AnswerverifiedC

Correct Answer
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Correct Answer
verified
Constitutional aplastic anemia...
View Answer

Correct Answer
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A

Correct Answer
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Correct Answer
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a.Good prognosis
b.G...
View Answer

Correct Answer
verified

Correct Answer
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B

Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
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a.Bone marrow toxicity
b.Toxicity to com...
View Answer

Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
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C