Question 1

Which of the following test results may help differentiate between intravascular hemolysis and extravascular hemolysis in the body?

Accepted Answer

A)  Hemoglobin
B)  Unconjugated bilirubin
C)  Splenomegaly
D)  Haptoglobin

Question 2

All of the following support the diagnosis of hemolytic anemia except:

Accepted Answer

A)  Low haptoglobin.
B)  Low hemoglobin.
C)  Reticulocyte count of 1%.
D)  Bilirubin above 2.5 mg/dL.

Question 3

Infections with Plasmodium cause __________ hemolysis.

Accepted Answer

A)  Intravascular
B)  Extravascular
C)  Both intravascular and extravascular
D)  It cannot be determined.

Question 4

Intravascular hemolysis releases this component into the circulation.

Accepted Answer

A)  Haptoglobin
B)  Hemoglobin
C)  Bilirubin
D)  Hemopexin

Question 5

The presence of schistocytes in the peripheral blood smear indicate:

Accepted Answer

A)  Hemolysis due to extracorpuscular defects.
B)  Hemolysis due to intracorpuscular defects.
C)  Hemolysis due to both extracorpuscular and intracorpuscular defects.
D)  Hemolysis with prominent bone marrow response. A

Question 6

A condition in which the rate of hemolysis equals the rate of bone marrow erythrocyte production is called:

Accepted Answer

A)  Intrinsic hemolytic anemia.
B)  Compensated hemolytic anemia.
C)  Extrinsic hemolytic anemia.
D)  Extravascular hemolysis.

Question 7

Which of the following is associated with intravascular hemolysis and not extravascular hemolysis?

Accepted Answer

A)  Hemosiderinuria
B)  Increased bilirubin
C)  Reticulocytosis
D)  Polychromasia on the blood smear

Question 8

Free hemoglobin released in intravascular hemolysis is bound to this protein and transported to the liver.

Accepted Answer

A)  Methemalbumin
B)  Carbon monoxide
C)  Haptoglobin
D)  Hemosiderin

Question 9

In severe intravascular hemolysis, synthesis of this protein may not be sufficient to what is being used to transport hemoglobin to the liver.

Accepted Answer

A)  Bilirubin
B)  Haptoglobin
C)  Albumin
D)  Methemoglobin

Question 10

The presence of spherocytes in peripheral circulation indicates which of the following?

Accepted Answer

A)  An intracorpuscular membrane defect
B)  An intracorpuscular enzyme defect
C)  An extracorpuscular membrane defect
D)  An extracorpuscular enzyme defect A

Question 11

What limits the degree of increased erythropoiesis in the bone marrow in the presence of hemolytic anemia?

Accepted Answer

A)  Amount of B₁₂ and folate stores
B)  Amount of iron that can be mobilized
C)  Quantity of stem cells in the BM
D)  Degree of extramedullary erythropoiesis

Question 12

Explain how the tests below differ for acute hemolytic anemia and compensated hemolytic anemia.
A)PB smear
B)Hemoglobin
C)Bone changes

Accepted Answer

a.PB smear: acute: schistocytes and sphe...

Question 13

Prosthetic heart valves can lead to an ________ form of hemolysis in which the predominating cell seen is a __________.

Accepted Answer

A)  Inherited; schistocyte
B)  Acquired; schistocyte
C)  Inherited; spherocyte
D)  Acquired; polychromasia

Question 14

This test result is helpful in assessing erythropoietic activity in the bone marrow in response to hemolysis in the peripheral blood.

Accepted Answer

A)  Myeloid-to-erythroid relation
B)  Plasma iron-to-erythroid iron index
C)  Reticulocyte production index
D)  MCV

Question 15

A laboratory professional is reviewing blood smears, and notices moderate spherocytes on one patient.What appropriate follow-up test would help determine the etiology of these cells?

Accepted Answer

A)  MCV
B)  Hemoglobin electrophoresis
C)  Direct antiglobulin test
D)  Unconjugated bilirubin

Question 16

A patient's laboratory tests show an increased LDH, a decreased haptoglobin, schistocytes, spherocytes, and polychromasia on the peripheral blood smear.Physical exam revealed splenomegaly.Excessive destruction of erythrocytes may be occurring in the:

Accepted Answer

A)  Blood vessels.
B)  Spleen.
C)  Marrow.
D)  Lymph nodes.

Question 17

Which results will help to differentiate between intravascular and extravascular hemolysis.

Accepted Answer

A)  Low hemoglobin in extravascular; normal hemoglobin in intravascular
B)  Low unconjugated bilirubin in extravascular; high unconjugated bilirubin in intravascular
C)  Presence of splenomegaly in intravascular; absence of splenomegaly in extravascular
D)  Normal haptoglobin in extravascular; low haptoglobin in intravascular

Question 18

Extravascular hemolysis due to a high degree of ineffective erythropoiesis is associated with:

Accepted Answer

A)  Cytoplasmic maturation defects.
B)  Autoimmune hemolytic anemia.
C)  Physical trauma to the erythrocyte.
D)  Snake venoms.

Question 19

The presence of blood in the urine indicates:

Accepted Answer

A)  Intravascular hemolysis.
B)  Extravascular hemolysis.
C)  Both intravascular and extravascular hemolysis.
D)  It cannot be determined. A

Question 20

Which of the following test results indicates that there is significant bone marrow turnover in response to hemolysis?

Accepted Answer

A)  Thrombocytosis
B)  Low RBC count
C)  High IRF
D)  Elevated bilirubin

Exam 13: Introduction to Hemolytic Anemia

Which of the following test results may help differentiate between intravascular hemolysis and extravascular hemolysis in the body?

Correct AnswerverifiedShow Answer

All of the following support the diagnosis of hemolytic anemia except:

Correct AnswerverifiedShow Answer

Infections with Plasmodium cause __________ hemolysis.

Correct AnswerverifiedShow Answer

Intravascular hemolysis releases this component into the circulation.

Correct AnswerverifiedShow Answer

The presence of schistocytes in the peripheral blood smear indicate:

Correct AnswerverifiedA

A condition in which the rate of hemolysis equals the rate of bone marrow erythrocyte production is called:

Correct AnswerverifiedShow Answer

Which of the following is associated with intravascular hemolysis and not extravascular hemolysis?

Correct AnswerverifiedShow Answer

Free hemoglobin released in intravascular hemolysis is bound to this protein and transported to the liver.

Correct AnswerverifiedShow Answer

In severe intravascular hemolysis, synthesis of this protein may not be sufficient to what is being used to transport hemoglobin to the liver.

Correct AnswerverifiedShow Answer

The presence of spherocytes in peripheral circulation indicates which of the following?

Correct AnswerverifiedA

What limits the degree of increased erythropoiesis in the bone marrow in the presence of hemolytic anemia?

Correct AnswerverifiedShow Answer

Explain how the tests below differ for acute hemolytic anemia and compensated hemolytic anemia. A)PB smear B)Hemoglobin C)Bone changes

Correct Answerverifieda.PB smear: acute: schistocytes and sphe...View AnswerShow Answer

Prosthetic heart valves can lead to an ________ form of hemolysis in which the predominating cell seen is a __________.

Correct AnswerverifiedShow Answer

This test result is helpful in assessing erythropoietic activity in the bone marrow in response to hemolysis in the peripheral blood.

Correct AnswerverifiedShow Answer

A laboratory professional is reviewing blood smears, and notices moderate spherocytes on one patient.What appropriate follow-up test would help determine the etiology of these cells?

Correct AnswerverifiedShow Answer

A patient's laboratory tests show an increased LDH, a decreased haptoglobin, schistocytes, spherocytes, and polychromasia on the peripheral blood smear.Physical exam revealed splenomegaly.Excessive destruction of erythrocytes may be occurring in the:

Correct AnswerverifiedShow Answer

Which results will help to differentiate between intravascular and extravascular hemolysis.

Correct AnswerverifiedShow Answer

Extravascular hemolysis due to a high degree of ineffective erythropoiesis is associated with:

Correct AnswerverifiedShow Answer

The presence of blood in the urine indicates:

Correct AnswerverifiedA

Which of the following test results indicates that there is significant bone marrow turnover in response to hemolysis?

Correct AnswerverifiedShow Answer

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a.PB smear: acute: schistocytes and sphe...
View Answer

Prosthetic heart valves can lead to an form of hemolysis in which the predominating cell seen is a __.

Correct Answer
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