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During elongation,the polypeptide is removed from the tRNA in the P site and transferred to the amino acid in the A site.

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The one-gene,one-enzyme hypothesis was first proposed by Beadle and Tatum.

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How many amino acids are encoded by the following mRNA? 5′GCCACCAUGGGCCAAUUACGAAGGUUUUGCUGA3′


A) 8
B) 9
C) 10
D) 11

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The wobble base is the second base of a codon.

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Proteins that are composed of two or more polypeptides are said to have quaternary structure.

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The scientist(s) ________ studied patients who had defects in their ability to metabolize certain compounds,particularly the inherited disease alkaptonuria.He/They proposed that a relationship exists between the inheritance of the trait and the inheritance of a defective enzyme.


A) Garrod 
B) Nirenberg and Matthaei
C) Khorana and colleagues
D) Nirenberg and Leder
E) Beadle and Tatum

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What site on the ribosome is primarily responsible for holding the growing polypeptide?


A) A
B) E
C) P

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61 different tRNAs are required for translation in vivo.

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Where are the ribosomal subunits assembled?


A) nucleus
B) nucleoid
C) nucleolus
D) nuclear envelope

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Based on our modern understanding,what revisions are necessary to the original one-gene / one-enzyme hypothesis?


A) Alternative splicing allows one gene to encode multiple polypeptides.
B) Some genes encode RNAs, not enzymes.
C) Some genes encode lipids, not enzymes.
D) Some genes encode polypeptides that are not enzymes, such as structural proteins.
E) Proteins as functional units may be composed of several polypeptides, so genes may encode just one polypeptide within a larger protein.

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Which molecule contains an anticodon?


A) DNA
B) mRNA
C) rRNA
D) tRNA
E) snRNA

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      What is the minimal number of tRNAs that can be used to recognize all of the codons for threonine? A)  1 B)  2 C)  3 D)  4         What is the minimal number of tRNAs that can be used to recognize all of the codons for threonine? A)  1 B)  2 C)  3 D)  4 What is the minimal number of tRNAs that can be used to recognize all of the codons for threonine?


A) 1
B) 2
C) 3
D) 4

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