Question 1

The primary point of control for most genes for the amount of gene product synthesized is

Accepted Answer

A)  termination of replication.
B)  transport of mRNA to the cytoplasm.
C)  initiation of transcription.
D)  alternative splicing.
E)  regulation of translation.

Question 2

Which of the following is NOT true of enhancer DNA sequences?

Accepted Answer

A)  They contain the TATA box regulatory element.
B)  They retain function if their nucleotide sequence is inverted.
C)  They can be more than 10 kilobases from the gene they regulate.
D)  They may increase or decrease gene transcription levels.
E)  They may contain multiple regulatory elements.

Question 3

Mutations altering the amount of protein synthesized from a reporter construct occur most often in which of the following sequences of DNA?

Accepted Answer

A)  the reporter gene
B)  cis-acting DNA elements
C)  X-gal coding sequence
D)  RNA polymerase II gene
E)  None of the choices is correct.

Question 4

tRNA molecules are transcribed by

Accepted Answer

A)  DNA pol II.
B)  DNA pol III.
C)  RNA pol I.
D)  RNA pol II.
E)  RNA pol III.

Question 5

The primary function of basal transcription factors is to

Accepted Answer

A)  repress transcription initiation of a particular gene.
B)  assist in associating RNA polymerase with the promoter element.
C)  increase transcription by binding enhancer sequences.
D)  activate RNA synthesis at origins of replication.
E)  regulate activity of DNA polymerase II.

Question 6

DNA regions that are transcriptionally silenced by hypercondensation have often undergone a modification of their cytosine residues termed

Accepted Answer

A)  hyperoxidation.
B)  methylation.
C)  dephosphorylation.
D)  phosphorylation.
E)  integration.

Question 7

The gene products encoded by trans-acting elements perform their function by

Accepted Answer

A)  associating with regulatory sequences distant from the gene from which they were transcribed.
B)  regulating the expression of the gene from which they were transcribed.
C)  the association of nucleotides with the elongating RNA transcript.
D)  physically associating with DNA polymerase.
E)  regulating the activity of telomerase.

Question 8

What is the term for the cis-acting DNA sequences that often function at a distance from the gene they are regulating?

Accepted Answer

A)  Promoter elements
B)  Terminator elements
C)  Enhancer elements
D)  Regulator elements
E)  Initiator elements

Question 9

The promoter of nearly all eukaryotic genes contains a(n)

Accepted Answer

A)  RNA polymerase binding region.
B)  TATA box.
C)  initiation site.
D)  TATA box and initiation site.
E)  RNA polymerase binding region, TATA box, and initiation site.

Question 10

A transcription factor that increases initiation of transcription by associating with an enhancer element is termed a(n)

Accepted Answer

A)  initiator.
B)  activator.
C)  repressor.
D)  enhancer.
E)  super-repressor.

Question 11

Proteins that consist of two identical polypeptide subunits are classified as

Accepted Answer

A)  monomers.
B)  oligomers.
C)  heterodimers.
D)  homodimers.
E)  diplomers.

Question 12

A cis-acting DNA sequence that modulates the basal rate of transcription of a gene is termed a(n)

Accepted Answer

A)  repressor.
B)  activator.
C)  promoter.
D)  enhancer.
E)  initiator.

Question 13

What is the term used to describe a situation in which a gene's expression pattern is dependent upon the parent from which it was inherited?

Accepted Answer

A)  Genomic imprinting
B)  Spermatogenesis
C)  Heterodimerization
D)  Homodimerization
E)  Gender-specific RNA stability

Question 14

The leucine zipper motif functions to

Accepted Answer

A)  mediate the physical association of two polypeptides.
B)  anchor transcriptional activator proteins to enhancer sequences.
C)  release leucines from misfolded transcription factors.
D)  integrate leucines and isoleucines into newly translated transcriptional activators.
E)  open up proteins after transcription.

Question 15

The ChIP technique can be used to identify putative DNA binding sites for various transcription factors since it

Accepted Answer

A)  identifies DNA sequences bound to specific proteins.
B)  identifies all sites bound by proteins in the nucleus.
C)  identifies the size of different protein-DNA complexes.
D)  indetifies proteins that can interact with mRNA.

Question 16

How is sex determined in Drosophila?

Accepted Answer

A)  Alternative splicing of SxI in females results in an active transcription factor that in turn results in the production of tra..
B)  Alternative splicing of SxI in females results in an inactive transcription factor that in turn results in the production of tra.
C)  The Y chromosome has 4 genes for different transcription factors that control the splicing of SxI.
D)  The Y chromosome has 4 genes for different transcription factors that control the transcription of SxI.

Question 17

In Drosophila females, Sxl protein associates with RNA alters the splicng pattern of the transcripts from which gene?

Accepted Answer

A)  sax
B)  max
C)  sxl
D)  myc
E)  SIR

Question 18

Which of the following is NOT a mechanism employed by repressor proteins to decrease transcription of a specific gene?

Accepted Answer

A)  The repressor associates with a promoter element, blocking RNA polymerase from binding promoter element.
B)  The repressor binds to the activation domain of an activator, eliminating its ability to increase transcription.
C)  The repressor binds to DNA-binding domain of an activator, eliminating its ability to associate with enhancer.
D)  The repressor binds to a DNA sequence in an enhancer, eliminating access to sequence by activator.
E)  The repressor binds to RNA polymerase II, blocking its ability to associate with promoter element.

Question 19

What is the name for the basal transcription factors that associate with TBP to assist in initiating transcription from eukaryotic class II genes?

Accepted Answer

A)  TATAs
B)  DNA- BPs
C)  TAFs
D)  Jun and Fos
E)  Sxl and string

Exam 16: Gene Regulation in Eukaryotes

How is sex determined in Drosophila?

Correct Answer
verified

The primary function of basal transcription factors is to

Correct Answer
verified

The primary point of control for most genes for the amount of gene product synthesized is

Correct Answer
verified

The promoter of nearly all eukaryotic genes contains a(n)

Correct Answer
verified

tRNA molecules are transcribed by

Correct Answer
verified

What is the term for the cis-acting DNA sequences that often function at a distance from the gene they are regulating?

Correct Answer
verified

What is the name for the basal transcription factors that associate with TBP to assist in initiating transcription from eukaryotic class II genes?

Correct Answer
verified

A cis-acting DNA sequence that modulates the basal rate of transcription of a gene is termed a(n)

Correct Answer
verified

DNA regions that are transcriptionally silenced by hypercondensation have often undergone a modification of their cytosine residues termed

Correct Answer
verified

Mutations altering the amount of protein synthesized from a reporter construct occur most often in which of the following sequences of DNA?

Correct Answer
verified

A transcription factor that increases initiation of transcription by associating with an enhancer element is termed a(n)

Correct Answer
verified

Which of the following is NOT a mechanism employed by repressor proteins to decrease transcription of a specific gene?

Correct Answer
verified

In Drosophila females, Sxl protein associates with RNA alters the splicng pattern of the transcripts from which gene?

Correct Answer
verified

The gene products encoded by trans-acting elements perform their function by

Correct Answer
verified

The ChIP technique can be used to identify putative DNA binding sites for various transcription factors since it

Correct Answer
verified

The leucine zipper motif functions to

Correct Answer
verified

What is the term used to describe a situation in which a gene's expression pattern is dependent upon the parent from which it was inherited?

Correct Answer
verified

Proteins that consist of two identical polypeptide subunits are classified as

Correct Answer
verified

Which of the following is NOT true of enhancer DNA sequences?

Correct Answer
verified

Exam 16: Gene Regulation in Eukaryotes

How is sex determined in Drosophila?

Correct AnswerverifiedShow Answer

The primary function of basal transcription factors is to

Correct AnswerverifiedShow Answer

The primary point of control for most genes for the amount of gene product synthesized is

Correct AnswerverifiedShow Answer

The promoter of nearly all eukaryotic genes contains a(n)

Correct AnswerverifiedShow Answer

tRNA molecules are transcribed by

Correct AnswerverifiedShow Answer

What is the term for the cis-acting DNA sequences that often function at a distance from the gene they are regulating?

Correct AnswerverifiedShow Answer

What is the name for the basal transcription factors that associate with TBP to assist in initiating transcription from eukaryotic class II genes?

Correct AnswerverifiedShow Answer

A cis-acting DNA sequence that modulates the basal rate of transcription of a gene is termed a(n)

Correct AnswerverifiedShow Answer

DNA regions that are transcriptionally silenced by hypercondensation have often undergone a modification of their cytosine residues termed

Correct AnswerverifiedShow Answer

Mutations altering the amount of protein synthesized from a reporter construct occur most often in which of the following sequences of DNA?

Correct AnswerverifiedShow Answer

A transcription factor that increases initiation of transcription by associating with an enhancer element is termed a(n)

Correct AnswerverifiedShow Answer

Which of the following is NOT a mechanism employed by repressor proteins to decrease transcription of a specific gene?

Correct AnswerverifiedShow Answer

In Drosophila females, Sxl protein associates with RNA alters the splicng pattern of the transcripts from which gene?

Correct AnswerverifiedShow Answer

The gene products encoded by trans-acting elements perform their function by

Correct AnswerverifiedShow Answer

The ChIP technique can be used to identify putative DNA binding sites for various transcription factors since it

Correct AnswerverifiedShow Answer

The leucine zipper motif functions to

Correct AnswerverifiedShow Answer

What is the term used to describe a situation in which a gene's expression pattern is dependent upon the parent from which it was inherited?

Correct AnswerverifiedShow Answer

Proteins that consist of two identical polypeptide subunits are classified as

Correct AnswerverifiedShow Answer

Which of the following is NOT true of enhancer DNA sequences?

Correct AnswerverifiedShow Answer

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