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Myelination in the human brain:


A) is complete upon birth.
B) is complete around the second birthday.
C) is complete sometime shortly after adolescence.
D) continues well into the adult years.

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____ steer new axonal branches and synapses in the right direction.


A) Chemokines
B) Immunoglobulin
C) Glia
D) Neurotrophins

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Chemicals known as ____ and ____ guide neuron migration.


A) immunoglobulins; sodium
B) glia; neurothrophins
C) immunoglobulins; chemokines
D) chemokines; neurothrophins

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Differentiation is the:


A) production of new cells.
B) movement of primitive neurons and glia.
C) formation of dendrites and an axon.
D) insulation process that occurs on some axons.

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After loss of sensory input from a limb, the axons representing that limb degenerate and:


A) cause immediate cell death.
B) leave vacant synaptic sites at several levels of the CNS.
C) destroy any leftover synapses.
D) cause no change in the associated neurons.

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The fluid-filled cavity of the developing neural tube becomes the:


A) forebrain.
B) midbrain.
C) spinal cord.
D) ventricular system.

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For some axons, glial cells produce an insulating sheath that makes rapid transmission possible. What is this process called?


A) Differentiation
B) Migration
C) Myelination
D) Proliferation

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Central nervous system axons regenerate much better in fish than in mammals because fish:


A) nerves do not have to travel so far to reach their target.
B) myelin does not secrete proteins that inhibit axon growth.
C) nerves have so much more myelin than do mammal nerves.
D) myelin secretes a protein that accelerates regeneration.

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Ischemia and hemorrhage kill neurons by:


A) understimulating them.
B) overstimulating them.
C) overactivating the sodium-potassium pump.
D) depleting the glutamate supply available to neurons.

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Tissue plasminogen activator (tPA) :


A) is recommended for hemorrhage.
B) overstimulates glutamate receptors.
C) should be administered a few days after stroke.
D) is helpful in cases of ischemia.

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A stroke caused by an artery rupturing is also known as:


A) ischemia.
B) hemorrhage.
C) closed head injury.
D) penumbra.

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An axon that does not receive enough neurotrophins from a target cell will:


A) branch out and form other synapses on other cells.
B) manufacture its own neurotrophins.
C) degenerate and die.
D) fail to reabsorb transmitters that have already been released.

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In response to nervous system injury, neurotrophins:


A) cause the neuron's death.
B) reduce inflammation due to this injury.
C) increase regrowth of damaged axons.
D) promote apoptosis.

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Paralysis caused by spinal cord injury is usually only temporary in humans.

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Damage to some of the axons that innervate a given structure may give rise to:


A) collateral sprouting, but not denervation supersensitivity.
B) denervation supersensitivity, but not collateral sprouting.
C) both collateral sprouting and denervation supersensitivity.
D) neither collateral sprouting nor denervation supersensitivity.

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Which of the following best describes the process by which developing axons find their general target areas?


A) completely random growth
B) shape attraction
C) electrical attraction
D) chemical attraction

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Define differentiation during neural development.

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A primitive (simple)...

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Which of the following are selective as axons form synapses with target cells?


A) axons, but not target cells
B) target cells, but not axons
C) both axons and target cells
D) neither axons nor target cells

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Mammals and amphibians are similar in that they can both easily generate new axons.

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If a brain area loses a set of incoming axons, we can expect some combination of ____ by the remaining axons and collateral sprouting by other axons that ordinarily attach to some other target.


A) disuse supersensitivity
B) decreased response
C) denervation supersensitivity
D) response supersensitivity

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