Question 1

What is an advantage of using chemically modified anti-D?

Accepted Answer

A)   It provides a low-protein medium.
B)   Rh control is not necessary.
C)   Few false-negative results are obtained.
D)   Du testing is eliminated.

Question 2

Anti-LW will react most strongly with:

Accepted Answer

A)   adult Rh-positive RBCs.
B)   Rh-negative RBCs.
C)   Rh-null RBCs.
D)   Rh-negative cord blood.

Question 3

Where is the Rh antigen located relative to the red blood cell membrane?

Accepted Answer

A)   Integrally
B)   Peripherally
C)   Centrally
D)   None of the above

Question 4

Which of the following Rh antigens is the most immunogenic?

Accepted Answer

A)   D
B)   C
C)   e
D)   E

Question 5

Most Rh antibodies are of what immunoglobulin class?

Accepted Answer

A)   IgM
B)   IgG
C)   IgA
D)   IgE

Question 6

What clinical manifestation may be associated with the Rh-null syndrome?

Accepted Answer

A)   Reticulocytosis
B)   Stomatocytosis
C)   Low hemoglobin
D)   All of the above

Question 7

All of the following are consistent with International Society of Blood Transfusion (ISBT)  terminology except:

Accepted Answer

A)   A six-digit number specifies each blood group antigen.
B)   004 represents Rh group.
C)   D is written as "R1."
D)   All genes are written in bold print.

Question 8

In which population is the genetic Du usually found?

Accepted Answer

A)   White
B)   Asian
C)   Black
D)   Native American

Question 9

When a patient has Rh-null syndrome, what kind of packed RBCs need to be transfused?

Accepted Answer

A)   ABO compatible Rh-positive blood
B)   ABO compatible Rh-negative blood
C)   ABO compatible Rh-null blood
D)   O-negative PRBCs

Question 10

The biochemical structure of the Rh antigens is a nonglycosylated protein, meaning:

Accepted Answer

A)   lipids are not attached to protein structure.
B)   carbohydrates are not attached to protein structure.
C)   glucose is attached to protein.
D)   glycerol is attached to protein.

Question 11

Which of the following reagents or methods is best for categorizing partial D types?

Accepted Answer

A)   Saline based anti-D
B)   High protein anti-D
C)   A combination of serological typing and molecular analysis
D)   Monoclonal anti-D reagents

Question 12

What does the term exalted D refer to?

Accepted Answer

A)   Deletion of the D antigen
B)   Stronger expression of Cc antigens when D is missing
C)   Stronger expression of Ee antigens when D is missing
D)   Stronger expression of D antigens when Cc and Ee are missing

Question 13

What is the frequency of E antigen in the general population?

Accepted Answer

A)   85%
B)   15%
C)   98%
D)   30%

Question 14

The Rh gene is located on which chromosome?

Accepted Answer

A)   1
B)   7
C)   9
D)   11

Question 15

Which of the following genotypes is consistent with f antigen expression?

Accepted Answer

A)   DcE/DCe
B)   Dce/DCE
C)   DCe/DcE
D)   DCe/dCE

Question 16

All of the following may cause a false-negative reaction in Rh typing except:

Accepted Answer

A)   omission of reagent.
B)   immunoglobulin coating cells.
C)   rouleaux.
D)   cell suspension that is too heavy.

Question 17

Why must there be alpha designations in the Rosenfield system?

Accepted Answer

A)   Nomenclature applies to other blood group systems besides Rh.
B)   Rosenfield nomenclature is only used in the Rh blood system.
C)   Weiner and Fisher-Race use alpha designations.
D)   None of the above

Question 18

What protocol is put in place to validate Rh testing when high-protein reagents are used, especially when the patient types as an AB-positive?

Accepted Answer

A)   Wash cells before testing
B)   Run a control with Rh test
C)   Add LISS to test system
D)   Use only saline reactive anti-D

Question 19

A cord blood sample was sent to the blood bank for a type and DAT. Cells were washed six times with saline before testing. The forward grouping typed as an O. There was no agglutination with anti-D and washed cord cells. The DAT was 3+ with polyspecific AHG. What is the Rh type of the baby?

Accepted Answer

A)   Rh-negative
B)   Rh-positive
C)   Rh type cannot be determined
D)   None of the above

Question 20

What does the "R" represent in Rh-Hr terminology?

Accepted Answer

A)   Absence of D antigen
B)   Presence of D antigen
C)   Presence of C antigen
D)   Presence of e antigen

Exam 7: The RH Blood Group System

All of the following are consistent with International Society of Blood Transfusion (ISBT) terminology except:

Correct AnswerverifiedShow Answer

When a patient has Rh-null syndrome, what kind of packed RBCs need to be transfused?

Correct AnswerverifiedShow Answer

Most Rh antibodies are of what immunoglobulin class?

Correct AnswerverifiedShow Answer

Why must there be alpha designations in the Rosenfield system?

Correct AnswerverifiedShow Answer

What is an advantage of using chemically modified anti-D?

Correct AnswerverifiedShow Answer

The biochemical structure of the Rh antigens is a nonglycosylated protein, meaning:

Correct AnswerverifiedShow Answer

What clinical manifestation may be associated with the Rh-null syndrome?

Correct AnswerverifiedShow Answer

Anti-LW will react most strongly with:

Correct AnswerverifiedShow Answer

Where is the Rh antigen located relative to the red blood cell membrane?

Correct AnswerverifiedShow Answer

What is the frequency of E antigen in the general population?

Correct AnswerverifiedShow Answer

What does the term exalted D refer to?

Correct AnswerverifiedShow Answer

Which of the following Rh antigens is the most immunogenic?

Correct AnswerverifiedShow Answer

What does the "R" represent in Rh-Hr terminology?

Correct AnswerverifiedShow Answer

The Rh gene is located on which chromosome?

Correct AnswerverifiedShow Answer

All of the following may cause a false-negative reaction in Rh typing except:

Correct AnswerverifiedShow Answer

Which of the following reagents or methods is best for categorizing partial D types?

Correct AnswerverifiedShow Answer

Which of the following genotypes is consistent with f antigen expression?

Correct AnswerverifiedShow Answer

In which population is the genetic Du usually found?

Correct AnswerverifiedShow Answer

What protocol is put in place to validate Rh testing when high-protein reagents are used, especially when the patient types as an AB-positive?

Correct AnswerverifiedShow Answer

A cord blood sample was sent to the blood bank for a type and DAT. Cells were washed six times with saline before testing. The forward grouping typed as an O. There was no agglutination with anti-D and washed cord cells. The DAT was 3+ with polyspecific AHG. What is the Rh type of the baby?

Correct AnswerverifiedShow Answer

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When a patient has Rh-nullsyndrome, what kind of packed RBCs need to be transfused?

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