Question 1

__________ activators are serine proteases present in the blood and a variety of other tissues, particularly the vascular endothelium.

Accepted Answer

A)   Exogenous
B)   Endogenous
C)   Xenogenous
D)   All of the above
E)   None of the above

Question 2

Heparin therapy is most effective in the __________ state of DIC with evident vascular thrombosis.

Accepted Answer

A)   Hypercoagulability
B)   Compensatory
C)   Decompensated
D)   All of the above
E)   None of the above

Question 3

What is the overall effect of 2-anti-plasmin inhibitor?

Accepted Answer

A)   Release free plasmin into circulation
B)   Limits plasmin activity to the area of fibrin deposition
C)   Inhibit clot lysis
D)   All of the above
E)   None of the above

Question 4

Thrombotic thrombocytopenic purpura (TTP)  represents an abnormality of the fibrinolytic system in which there is diminished __________ activity in plasma and blood vessels affected with microthrombi.

Accepted Answer

A)   Tissue thromboplastin
B)   TPA
C)   Thrombin
D)   Protein C
E)   None of the above

Question 5

Blood component replacement therapy in DIC includes transfusion of:

Accepted Answer

A)   Packed red blood cells
B)   Fresh frozen plasma
C)   Platelets
D)   Cryoprecipitate
E)   All of the above

Question 6

The clinical picture in DIC is dependent on:

Accepted Answer

A)   Duration of the triggering stimulus
B)   Functional ability of the reticuloendothelial system (RES)  to remove activated coagulation factors
C)   Compensatory ability of the liver and bone marrow to accelerate platelet production
D)   Organ involvement
E)   All of the above

Question 7

All of the following are known mechanisms for activation of the coagulation cascade except:

Accepted Answer

A)   Activation of the extrinsic coagulation pathway by factor XIa
B)   Activation of the extrinsic coagulation pathway by the release of tissue thromboplastin
C)   Activation of the intrinsic coagulation pathway by factor XIIa
D)   Direct activation of factor X or II
E)   None of the above

Question 8

Thrombin-anti-thrombin complexes are elevated in which of the following conditions?

Accepted Answer

A)   TTP
B)   DIC
C)   Primary fibrinolysis
D)   Heparin therapy
E)   None of the above B

Question 9

DIC associated with conditions activated by factor X include which of the following?

Accepted Answer

A)   Acute pancreatitis
B)   Snake venom
C)   Liver disease
D)   Fat emboli syndrome
E)   All of the above

Question 10

Which of the following are characteristics of urokinase?

Accepted Answer

A)   Synthesized by the kidney
B)   Low affinity for fibrin
C)   Excreted in the urine
D)   None of the above
E)   All of the above

Question 11

What red cell morphology might you expect in DIC?

Accepted Answer

A)   Ovalocytes
B)   Teardrop cells
C)   Schistocytes
D)   Target cells
E)   None of the above

Question 12

Which laboratory tests are abnormal in DIC?

Accepted Answer

A)   Prothrombin time (PT) 
B)   Activated partial thromboplastin time (APTT) 
C)   Reptilase clotting time
D)   Thrombin time (TT) 
E)   All of the above

Question 13

The molecular components of the fibrinolytic system consist of all of the following except:

Accepted Answer

A)   Plasminogen
B)   Plasmin
C)   Thrombin
D)   α2-anti-Plasmin inhibitor
E)   Fibrin/fibrinogen C

Question 14

Native plasminogen is a single-chain plasma __________ of approximately 90,000 daltons that circulates in two molecular forms.

Accepted Answer

A)   Chromogen
B)   Zymogen
C)   Mitogen
D)   All of the above
E)   None of the above

Question 15

Diffuse hemorrhage present in DIC is the result of:

Accepted Answer

A)   Increased platelets/decreased coagulation factors
B)   Decreased platelets/increased coagulation factors
C)   Decreased platelets/decreased coagulation factors
D)   Vascular occlusion
E)   None of the above

Question 16

The secondary action of the fibrinolytic system in DIC involves the action of __________ on fibrin/fibrinogen.

Accepted Answer

A)   Thrombin
B)   Prothrombin
C)   Plasmin
D)   Plasminogen
E)   None of the above

Question 17

Which laboratory test differentiates compensated DIC from a state of hypercoagulability DIC?

Accepted Answer

A)   PT
B)   APTT
C)   TT
D)   Reptilase time
E)   None of the above

Question 18

Which serine protease proteolytically degrades both fibrin in clots and native fibrinogen in the circulation into a series of well-characterized end-products collectively known as fibrin/fibrinogen degradation products?

Accepted Answer

A)   Protein C
B)   Plasmin
C)   Kallikrein
D)   Plasminogen
E)   None of the above B

Question 19

Streptokinase forms a 1:1 stoichiometric complex with __________.

Accepted Answer

A)   Plasmin
B)   Plasminogen
C)   Thrombin
D)   Prothrombin
E)   None of the above

Question 20

Which of the following is/are consistent with a compensated state of DIC?

Accepted Answer

A)   Increased fibrinopeptide A
B)   Soluble fibrin monomer complexes
C)   Increased FDPs
D)   Increased D-dimer levels
E)   All of the above

Exam 27: Interaction of the Fibrinolytic, Coagulation, and Kinin Systems; Disseminated Intravascular Coagulation; and Related Pathology

__________ activators are serine proteases present in the blood and a variety of other tissues, particularly the vascular endothelium.

Correct AnswerverifiedShow Answer

Heparin therapy is most effective in the __________ state of DIC with evident vascular thrombosis.

Correct AnswerverifiedShow Answer

What is the overall effect of 2-anti-plasmin inhibitor?

Correct AnswerverifiedShow Answer

Thrombotic thrombocytopenic purpura (TTP) represents an abnormality of the fibrinolytic system in which there is diminished __________ activity in plasma and blood vessels affected with microthrombi.

Correct AnswerverifiedShow Answer

Blood component replacement therapy in DIC includes transfusion of:

Correct AnswerverifiedShow Answer

The clinical picture in DIC is dependent on:

Correct AnswerverifiedShow Answer

All of the following are known mechanisms for activation of the coagulation cascade except:

Correct AnswerverifiedShow Answer

Thrombin-anti-thrombin complexes are elevated in which of the following conditions?

Correct AnswerverifiedB

DIC associated with conditions activated by factor X include which of the following?

Correct AnswerverifiedShow Answer

Which of the following are characteristics of urokinase?

Correct AnswerverifiedShow Answer

What red cell morphology might you expect in DIC?

Correct AnswerverifiedShow Answer

Which laboratory tests are abnormal in DIC?

Correct AnswerverifiedShow Answer

The molecular components of the fibrinolytic system consist of all of the following except:

Correct AnswerverifiedC

Native plasminogen is a single-chain plasma __________ of approximately 90,000 daltons that circulates in two molecular forms.

Correct AnswerverifiedShow Answer

Diffuse hemorrhage present in DIC is the result of:

Correct AnswerverifiedShow Answer

The secondary action of the fibrinolytic system in DIC involves the action of __________ on fibrin/fibrinogen.

Correct AnswerverifiedShow Answer

Which laboratory test differentiates compensated DIC from a state of hypercoagulability DIC?

Correct AnswerverifiedShow Answer

Which serine protease proteolytically degrades both fibrin in clots and native fibrinogen in the circulation into a series of well-characterized end-products collectively known as fibrin/fibrinogen degradation products?

Correct AnswerverifiedB

Streptokinase forms a 1:1 stoichiometric complex with __________.

Correct AnswerverifiedShow Answer

Which of the following is/are consistent with a compensated state of DIC?

Correct AnswerverifiedShow Answer

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What is the overall effect of ₂-anti-plasmin inhibitor?

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B

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C

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B

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