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Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -Serine and threonine are deaminated by the enzyme _______________.


A) hyperammonemia
B) aminotransferases
C) methionine
D) S-adenosylmethionine
E) glutamate dehydrogenase
F) oxaloacetate
G) biopterin
H) glutamate
I) hippurate
J) urea
K) dehydratase
L) dioxygenases
M) ammonia disorder

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Which of the following is an allosteric activator of mammalian carbamoyl phosphate synthetase?


A) α-ketoglutarate
B) N-acetylaspartate
C) N-acetylglutamate
D) glutamine
E) None of the above.

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Write the net equation of the urea cycle and indicate whether energy is produced or consumed by the cycle.

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CO2 + NH4+ + 3 ATP + Asp + 2 H...

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Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -The methyl group donor _______________ is the product of the first step of methionine degradation.


A) hyperammonemia
B) aminotransferases
C) methionine
D) S-adenosylmethionine
E) glutamate dehydrogenase
F) oxaloacetate
G) biopterin
H) glutamate
I) hippurate
J) urea
K) dehydratase
L) dioxygenases
M) ammonia disorder

Correct Answer

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Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -The molecule _______________ is formed from excess NH4+ by ureotelic organisms.


A) hyperammonemia
B) aminotransferases
C) methionine
D) S-adenosylmethionine
E) glutamate dehydrogenase
F) oxaloacetate
G) biopterin
H) glutamate
I) hippurate
J) urea
K) dehydratase
L) dioxygenases
M) ammonia disorder

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Which amino acids can be converted to pyruvate by a single enzyme-catalyzed reaction?

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Alanine can be converted to py...

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Oxidative deamination of glutamate results in free ammonium ions and ___________________.

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Why are more uricotelic organisms found in the desert than in the tropics?

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Uricotelic organisms remove to...

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Which of the following amino acids is/are glucogenic?


A) asparagine
B) methionine
C) valine
D) lysine
E) A, B, and C

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The genetic deficiency of the enzyme ___________________ results in a condition referred to as phenylketonuria.

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phenylalan...

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How is the urea cycle linked to the citric acid cycle?

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During the urea cycle, aspartate brings in the second nitrogen by combining with citrulline to form argininosuccinate. Then argininosuccinate is cleaved, forming arginine and fumarate. The fumarate is then converted into malate and then oxidized to oxaloacetate, which can be transaminated to aspartate or serve as a precursor to glucose. Fumarate, malate, and oxaloacetate are all intermediates of the citric acid cycle. Figure 30.3 in the text shows this integration.

In the urea cycle, the second nitrogen of urea enters the cycle in the form of which of the following metabolites?


A) alanine
B) glutamine
C) ornithine
D) aspartate
E) arginine

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Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -The molecule _______________ is oxidatively deaminated to an ammonium ion.


A) hyperammonemia
B) aminotransferases
C) methionine
D) S-adenosylmethionine
E) glutamate dehydrogenase
F) oxaloacetate
G) biopterin
H) glutamate
I) hippurate
J) urea
K) dehydratase
L) dioxygenases
M) ammonia disorder

Correct Answer

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H

What is the cause of PKU? Give the structure of the abnormal metabolite that accumulates from which this condition gets its name.

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PKU is the abbreviation for phenylketonu...

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Which of the following amino acids is/are ketogenic?


A) asparagine
B) methionine
C) valine
D) lysine
E) A, B, and C

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Describe the glucose-alanine cycle and its significance in amino acid metabolism.

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During prolonged exercise and fasting, muscles use branched-chain amino acids as fuel. This degradation takes place in the muscle, but conversion to urea is not possible in this tissue, thus transport to the liver is required. The amino nitrogen is removed by transamination to produce glutamate. The glutamate then transaminates with pyruvate, producing alanine, which is released into the blood and transported to the liver. In the liver, the alanine is converted to pyruvate and the urea is metabolized to urea. The pyruvate is converted to glucose by gluconeogenesis and the glucose is transported back to the muscle via the bloodstream.

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -The _______________ enzyme catalyzes an oxidative deamination and can utilize either NAD+ or NADP+.


A) hyperammonemia
B) aminotransferases
C) methionine
D) S-adenosylmethionine
E) glutamate dehydrogenase
F) oxaloacetate
G) biopterin
H) glutamate
I) hippurate
J) urea
K) dehydratase
L) dioxygenases
M) ammonia disorder

Correct Answer

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Surplus amino acids are:


A) stored in proteasomes.
B) stored in protein scaffolds.
C) used as metabolic fuel.
D) All of the above.
E) None of the above.

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Ammoniotelic organisms excrete excess nitrogen as:


A) N2H8.
B) NH4+.
C) urea.
D) All of the above.
E) None of the above.

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Which amino acid(s) is/are converted to tyrosine in the degradative pathway?


A) phenylalanine
B) tryptophan
C) methionine
D) A and B
E) A, B, and C

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