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How is the pentose phosphate pathway regulated?

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The level of NADP+ is very important in ...

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The pentose phosphate pathway:


A) is stimulated by NADH.
B) is stimulated by NADPH.
C) operates primarily in nondividing cells.
D) is contained within the mitochondria of adipose cells.
E) None of the above.

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____________ is a substrate for the pentose phosphate pathway.


A) nonoxidative
B) oxidative
C) transketolase
D) glucose 6-phosphate
E) reducing equivalents
F) thiamine pyrophosphate
G) transaldolase
H) glutathione reductase
I) glycolysis
J) NADH
K) fructose 6-phosphate
L) NADPH/pentose phosphate pathway
M) glucose

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D

The prosthetic group ____________ is tightly bound to the enzyme transketolase.


A) nonoxidative
B) oxidative
C) transketolase
D) glucose 6-phosphate
E) reducing equivalents
F) thiamine pyrophosphate
G) transaldolase
H) glutathione reductase
I) glycolysis
J) NADH
K) fructose 6-phosphate
L) NADPH/pentose phosphate pathway
M) glucose

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NADPH is required for which of the following detoxification reactions or enzymes?


A) cytochrome P450 monooxygenase
B) reduction of glutathione(ox)
C) deamination of serine
D) A and B
E) All of the above.

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A deficiency of glucose 6-phosphate can cause hemolytic anemia. This is due to a loss in activity in which enzyme in red blood cells?


A) nonoxidative
B) oxidative
C) transketolase
D) glucose 6-phosphate
E) reducing equivalents
F) thiamine pyrophosphate
G) transaldolase
H) glutathione reductase
I) glycolysis
J) NADH
K) fructose 6-phosphate
L) NADPH/pentose phosphate pathway
M) glucose

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Excess carbons of the pentose phosphate pathway are shunted to what other metabolic pathway?


A) nonoxidative
B) oxidative
C) transketolase
D) glucose 6-phosphate
E) reducing equivalents
F) thiamine pyrophosphate
G) transaldolase
H) glutathione reductase
I) glycolysis
J) NADH
K) fructose 6-phosphate
L) NADPH/pentose phosphate pathway
M) glucose

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Under what conditions might the pentose phosphate pathway produce large amounts of NADPH without significant net production of ribose 5-phosphate?


A) synthesis of fatty acids in the liver
B) when pyruvate is synthesized to generate ATP
C) when cells are rapidly dividing
D) A and C
E) B and C

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Reduced glutathione maintains red blood cell structure by:


A) protecting against falciparum malaria.
B) maintaining hemoglobin structure.
C) preventing Heinz body formation.
D) A and C.
E) B and C.

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What are the reactions in the oxidative phase of the pentose phosphate pathway?

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The first reaction is the oxidation of C...

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Which enzyme controls the pentose phosphate pathway?

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While the overall rate of the ...

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The oxidative phase of the pentose phosphate pathway produces _________________, which is required for lipid biosynthesis.

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NADPH

The second phase of the pentose phosphate pathway is the ____________ phase.


A) nonoxidative
B) oxidative
C) transketolase
D) glucose 6-phosphate
E) reducing equivalents
F) thiamine pyrophosphate
G) transaldolase
H) glutathione reductase
I) glycolysis
J) NADH
K) fructose 6-phosphate
L) NADPH/pentose phosphate pathway
M) glucose

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Which of the following reactions is not part of the pentose phosphate pathway?


A) Which of the following reactions is not part of the pentose phosphate pathway? A)    B)   C)    D)    E)  All of the above.
B) Which of the following reactions is not part of the pentose phosphate pathway? A)    B)   C)    D)    E)  All of the above.
C) Which of the following reactions is not part of the pentose phosphate pathway? A)    B)   C)    D)    E)  All of the above.
D) Which of the following reactions is not part of the pentose phosphate pathway? A)    B)   C)    D)    E)  All of the above.
E) All of the above.

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In the nonoxidative stage of the pentose phosphate pathway, intermediates of _____________ are produced.


A) the citric acid cycle
B) glycolysis
C) glycogen degradation
D) A and C
E) B and C

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Ribulose 5-phosphate is the result of the ____________ phase.


A) nonoxidative
B) oxidative
C) transketolase
D) glucose 6-phosphate
E) reducing equivalents
F) thiamine pyrophosphate
G) transaldolase
H) glutathione reductase
I) glycolysis
J) NADH
K) fructose 6-phosphate
L) NADPH/pentose phosphate pathway
M) glucose

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ATP is called the energy currency. The currency of reducing power is:


A) NADPH.
B) NADH.
C) AMP.
D) ADP.
E) None of the above.

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A

The two key components required for growth are _________________ and biochemical reducing power.

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What is the net reaction of the transketolase and transaldolase steps?


A) 3C52C6 + C3
B) 2C5C6 + C4
C) 3C5C6 + 3C3
D) 2C52C4 + C2
E) None of the above.

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______________ oxidizes the C3 hydroxyl to a ketone.


A) Lactonase
B) Glucose 6-phosphate dehydrogenase
C) Transaldolase
D) Transketolase
E) 6-phosphogluconate dehydrogenase

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