Question 1

A particular cell contains all of the standard histones but lacks several histone variants. Which of the following MAY be true of this cell?

Accepted Answer

A)   The cell will be completely unable to remodel its chromatin.
B)   The cell will have an enhanced ability to chemically modify its histones.
C)   The cell will be unable to express any of its genes at all.
D)   The cell will express different sets of genes than other cells in the same organism.
E)   The cell will not be able to divide.F) A) and B)
G) A) and C)

Question 2

When a glucocorticoid hormone binds to the glucocorticoid receptor, HSP90 is released.

Accepted Answer

A) True 
 B)False

Question 3

What activates CREB?

Accepted Answer

A)   Binding of cAMP
B)   Phosphorylation
C)   Dimerization
D)   Lowering of cAMP concentration
E)   Binding to GREF) B) and D)
G) C) and D)

Question 4

Which of the following is a region in DNA that binds to a steroid receptor?

Accepted Answer

A)   GRE
B)   IRE
C)   CRE
D)   CREBE) None of the above
F) B) and D)

Question 5

What would be the result of a mutation in Hsp90 that prevented its binding to the glucocorticoid receptor?

Accepted Answer

A)   Glucocorticoid receptor could not form a dimer
B)   The nuclear localization signal would no longer function
C)   Expression of the regulated genes would become constitutive
D)   The hormone would not be able to bind to the glucocorticoid receptorE) None of the above
F) B) and C)

Question 6

What might happen if the insulator between two genes is missing?

Accepted Answer

A)   Without the insulator, neither gene can be transcribed.
B)   Transcription factors influencing one gene's expression may abnormally influence a neighboring gene's expression.
C)   Transcription factors will not be able to influence the expression of either gene.
D)   Without insulation, both genes will be expressed at maximal levels.
E)   Transcription factors will not be able to bind to the insulator.F) C) and D)
G) None of the above

Question 7

Which of the following recognizes response elements, control elements, and regulatory elements?

Accepted Answer

A)   General transcription factors
B)   Regulatory transcription factors
C)   Mediator
D)   Transactivation domainsE) C) and D)
F) None of the above

Question 8

For which of the following histones has variant forms not yet been identified?

Accepted Answer

A)   H1
B)   H2A
C)   H2B
D)   H3
E)   H4F) B) and E)
G) None of the above

Question 9

In the presence of abundant iron in the cell, the iron binds IRP. The complex is then released from IREs leading to

Accepted Answer

A)   an increase in ferritin mRNA translation and a decrease in transferrin receptor mRNA stability.
B)   an increase in transferrin receptor mRNA stability and a decrease in ferritin mRNA translation.
C)   an increase in transferrin receptor mRNA stability and ferritin mRNA translation.
D)   an decrease in transferrin receptor mRNA stability and ferritin mRNA translation.E) C) and D)
F) A) and B)

Question 10

A transactivation domain is an example of a motif found in transcription factors.

Accepted Answer

A) True 
 B)False

Question 11

Histone acetyltransferases are directly involved in which of the following?

Accepted Answer

A)   Removal of histones from chromatin
B)   Movement of nucleosomes
C)   Chemical modification of histones
D)   Termination of gene expression
E)   Insertion of variant histone proteinsF) D) and E)
G) A) and D)

Question 12

Which one of the following directly interacts with the DNA as a transcriptional regulator?

Accepted Answer

A)   cAMP
B)   G protein
C)   Protein kinase A
D)   CREB protein dimer
E)   Glucocorticoid response elementF) C) and D)
G) None of the above

Question 13

Which of the following is a major finding from the ENCODE project?

Accepted Answer

A)   More than 80% of the human genome sequence is linked to a biological function.
B)   In humans, one gene encodes exactly one protein.
C)   Genes were identified for all known diseases.
D)   There are more than 10 million regulatory sites in human DNA.E) B) and C)
F) A) and B)

Question 14

Steroid hormones are an example of an effector which regulates regulatory transcription factor activity.

Accepted Answer

A) True 
 B)False

Question 15

Which DNA sequence important for gene expression is usually contained within the NFR?

Accepted Answer

A)   Core promoter
B)   CREB binding site
C)   Histone binding site
D)   Transcription termination sequence
E)   Hormone response elementF) A) and E)
G) B) and E)

Question 16

Which of the following is the most likely location of an insulator sequence?

Accepted Answer

A)   At the end of a gene
B)   In the middle of a gene
C)   At the beginning of a gene
D)   Between two genes
E)   Within an intronF) C) and E)
G) None of the above

Question 17

Transcription factors are proteins that influence the ability of the RNA polymerase to transcribe a gene.

Accepted Answer

A) True 
 B)False

Question 18

The activity of some transcription factors can be regulated by covalent modifications.

Accepted Answer

A) True 
 B)False

Question 19

cAMP is known as a second messenger since the pathway is first activated by a extracellular signaling molecule.

Accepted Answer

A) True 
 B)False

Exam 15: Gene Regulation in Eukaryotes I: Transcriptional and Translation Regulation

What might happen if the insulator between two genes is missing?

Correct Answer
verified

In the presence of abundant iron in the cell, the iron binds IRP. The complex is then released from IREs leading to

Correct Answer
verified

What activates CREB?

Correct Answer
verified

A transactivation domain is an example of a motif found in transcription factors.

Correct Answer
verified

Which of the following is a region in DNA that binds to a steroid receptor?

Correct Answer
verified

Which one of the following directly interacts with the DNA as a transcriptional regulator?

Correct Answer
verified

When a glucocorticoid hormone binds to the glucocorticoid receptor, HSP90 is released.

Correct Answer
verified

Which of the following recognizes response elements, control elements, and regulatory elements?

Correct Answer
verified

The activity of some transcription factors can be regulated by covalent modifications.

Correct Answer
verified

cAMP is known as a second messenger since the pathway is first activated by a extracellular signaling molecule.

Correct Answer
verified

Which of the following is a major finding from the ENCODE project?

Correct Answer
verified

For which of the following histones has variant forms not yet been identified?

Correct Answer
verified

Which DNA sequence important for gene expression is usually contained within the NFR?

Correct Answer
verified

Histone acetyltransferases are directly involved in which of the following?

Correct Answer
verified

A particular cell contains all of the standard histones but lacks several histone variants. Which of the following MAY be true of this cell?

Correct Answer
verified

Transcription factors are proteins that influence the ability of the RNA polymerase to transcribe a gene.

Correct Answer
verified

Steroid hormones are an example of an effector which regulates regulatory transcription factor activity.

Correct Answer
verified

What would be the result of a mutation in Hsp90 that prevented its binding to the glucocorticoid receptor?

Correct Answer
verified

Which of the following is the most likely location of an insulator sequence?

Correct Answer
verified

Exam 15: Gene Regulation in Eukaryotes I: Transcriptional and Translation Regulation

What might happen if the insulator between two genes is missing?

Correct AnswerverifiedShow Answer

In the presence of abundant iron in the cell, the iron binds IRP. The complex is then released from IREs leading to

Correct AnswerverifiedShow Answer

What activates CREB?

Correct AnswerverifiedShow Answer

A transactivation domain is an example of a motif found in transcription factors.

Correct AnswerverifiedShow Answer

Which of the following is a region in DNA that binds to a steroid receptor?

Correct AnswerverifiedShow Answer

Which one of the following directly interacts with the DNA as a transcriptional regulator?

Correct AnswerverifiedShow Answer

When a glucocorticoid hormone binds to the glucocorticoid receptor, HSP90 is released.

Correct AnswerverifiedShow Answer

Which of the following recognizes response elements, control elements, and regulatory elements?

Correct AnswerverifiedShow Answer

The activity of some transcription factors can be regulated by covalent modifications.

Correct AnswerverifiedShow Answer

cAMP is known as a second messenger since the pathway is first activated by a extracellular signaling molecule.

Correct AnswerverifiedShow Answer

Which of the following is a major finding from the ENCODE project?

Correct AnswerverifiedShow Answer

For which of the following histones has variant forms not yet been identified?

Correct AnswerverifiedShow Answer

Which DNA sequence important for gene expression is usually contained within the NFR?

Correct AnswerverifiedShow Answer

Histone acetyltransferases are directly involved in which of the following?

Correct AnswerverifiedShow Answer

A particular cell contains all of the standard histones but lacks several histone variants. Which of the following MAY be true of this cell?

Correct AnswerverifiedShow Answer

Transcription factors are proteins that influence the ability of the RNA polymerase to transcribe a gene.

Correct AnswerverifiedShow Answer

Steroid hormones are an example of an effector which regulates regulatory transcription factor activity.

Correct AnswerverifiedShow Answer

What would be the result of a mutation in Hsp90 that prevented its binding to the glucocorticoid receptor?

Correct AnswerverifiedShow Answer

Which of the following is the most likely location of an insulator sequence?

Correct AnswerverifiedShow Answer

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