Question 1

What basal transcription factor is a helicase?

Accepted Answer

A)   TFIID
B)   TFIIH
C)   TFIIF
D)   TFIIB

Question 2

If a nucleotide in a eukaryotic mRNA coding sequence does not appear in the genomic DNA sequence the most likely modification to have occurred is

Accepted Answer

A)   Alternative splicing
B)   RNA editing
C)   5' capping
D)   Polyadenylation
E)   Trimming

Question 3

What is the purpose of phosphorylating the carboxy terminal domain (CTD) ?

Accepted Answer

A)   Convert from initiation to the elongation stage
B)   To aid in transcriptional initiation
C)   Phosphorylate transcription factors
D)   To aid in promoter recognition

Question 4

What percentage of human pre-mRNA is alternatively spliced

Accepted Answer

A)   70 %
B)   23%
C)   5%
D)   2%

Question 5

What RNAs do each eukaryotic RNA polymerase produce?

Accepted Answer

A)   RNA pol I - mRNA RNA pol II - tRNA and 5s rRNARNA pol III - rRNA
B)   RNA pol I - rRNA RNA pol II - tRNA and 5s rRNARNA pol III - mRNA
C)   RNA pol I - mRNA RNA pol II - rRNARNA pol III - tRNA and 5s rRNA
D)   RNA pol I - rRNA RNA pol II - mRNARNA pol III - tRNA and 5s rRNA

Question 6

The RNA polymerase forms a closed complex during the process of elongation during transcription.

Accepted Answer

A) True 
 B)False

Question 7

The process of RNA editing can alter the base sequence of the mRNA following transcription.

Accepted Answer

A) True 
 B)False

Question 8

RNaseP is not a protein but a ribozyme

Accepted Answer

A) True 
 B)False

Question 9

Prokaryotic genes are colinear with their proteins, but this is not true for most eukaryotic genes

Accepted Answer

A)   True
B)   False
C)   It is unknown at this time

Question 10

The Prinbow box contains a CACAAC consensus sequence located in the -100 region of the promoter.

Accepted Answer

A) True 
 B)False

Question 11

What region in eukaryotic genes usually contains the majority of regulatory elements such as GC and CAAT boxes?

Accepted Answer

A)   0 to 50
B)   -50 to 0
C)   -50 to -100
D)   -100 to -150

Question 12

A main function of TFIID is

Accepted Answer

A)   to recognize the TATA box
B)   to act as a helicase
C)   to terminate RNA polymerase II binding
D)   to phosphorylate the CTD of RNA polymerase II

Question 13

What snRNP holds the exons in place so that they can be connected after the intron is removed?

Accepted Answer

A)   U1
B)   U2
C)   U5
D)   U6

Question 14

In eukaryotic organisms, the processing of the 45S rRNA into 5.8S, 18S, and 28S rRNA occurs where?

Accepted Answer

A)   In the cytoplasm
B)   In the nucleolus
C)   In the endoplasmic reticulum
D)   In the Golgi body
E)   Throughout the cell

Question 15

The term ribozyme is given to catalytic RNA molecules.

Accepted Answer

A) True 
 B)False

Question 16

During the initiation phase of transcription the sigma (σ) factor, which is bound to RNA polymerase, binds into the major groove of DNA and recognizes sequence elements at the promoter. This process forms a closed complex

Accepted Answer

A) True 
 B)False

Question 17

What occurs In both prokaryotic and eukaryotic tRNA maturation?

Accepted Answer

A)   The pre tRNA molecule is trimmed by exo and endonucleases
B)   The pre tRNA is spliced
C)   The mature tRNA is capped at the 5' end
D)   There is extensive RNA editing

Question 18

What structural motif is most commonly used by transcription factors in binding to DNA?

Accepted Answer

A)   Zinc-finger
B)   Helix-turn-helix
C)   Leucine zipper
D)   Homeodomain

Question 19

Where does the process of transcription initiate?

Accepted Answer

A)   Promoter
B)   Terminator
C)   Regulation sequences
D)   Transcription factors

Question 20

What modification acts to stabilize eukaryotic mRNA?

Accepted Answer

A)   Alternative splicing
B)   RNA editing
C)   RNA interference
D)   Polyadenylation
E)   Trimming

Exam 12: Gene Transcription and Rna Modification

RNaseP is not a protein but a ribozyme

Correct AnswerverifiedShow Answer

What RNAs do each eukaryotic RNA polymerase produce?

Correct AnswerverifiedShow Answer

During the initiation phase of transcription the sigma (σ) factor, which is bound to RNA polymerase, binds into the major groove of DNA and recognizes sequence elements at the promoter. This process forms a closed complex

Correct AnswerverifiedShow Answer

The Prinbow box contains a CACAAC consensus sequence located in the -100 region of the promoter.

Correct AnswerverifiedShow Answer

Prokaryotic genes are colinear with their proteins, but this is not true for most eukaryotic genes

Correct AnswerverifiedShow Answer

What percentage of human pre-mRNA is alternatively spliced

Correct AnswerverifiedShow Answer

What structural motif is most commonly used by transcription factors in binding to DNA?

Correct AnswerverifiedShow Answer

The RNA polymerase forms a closed complex during the process of elongation during transcription.

Correct AnswerverifiedShow Answer

What snRNP holds the exons in place so that they can be connected after the intron is removed?

Correct AnswerverifiedShow Answer

In eukaryotic organisms, the processing of the 45S rRNA into 5.8S, 18S, and 28S rRNA occurs where?

Correct AnswerverifiedShow Answer

What region in eukaryotic genes usually contains the majority of regulatory elements such as GC and CAAT boxes?

Correct AnswerverifiedShow Answer

A main function of TFIID is

Correct AnswerverifiedShow Answer

The term ribozyme is given to catalytic RNA molecules.

Correct AnswerverifiedShow Answer

What is the purpose of phosphorylating the carboxy terminal domain (CTD) ?

Correct AnswerverifiedShow Answer

What occurs In both prokaryotic and eukaryotic tRNA maturation?

Correct AnswerverifiedShow Answer

If a nucleotide in a eukaryotic mRNA coding sequence does not appear in the genomic DNA sequence the most likely modification to have occurred is

Correct AnswerverifiedShow Answer

What modification acts to stabilize eukaryotic mRNA?

Correct AnswerverifiedShow Answer

What basal transcription factor is a helicase?

Correct AnswerverifiedShow Answer

Where does the process of transcription initiate?

Correct AnswerverifiedShow Answer

The process of RNA editing can alter the base sequence of the mRNA following transcription.

Correct AnswerverifiedShow Answer

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