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Using visual observation of phenotypes to identify allele frequency rarely works because:


A) most alleles are recessive and will not produce a visible phenotype.
B) phenotype is not due to the alleles.
C) multiple genes may control the phenotype.
D) visual phenotypes are rare.
E) phenotype is not an indication of genotype.

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A gene in a diploid species has five different alleles. In any one population, the allele frequencies of all five alleles must add up to:


A) one.
B) two.
C) five.
D) ten.

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Why is DNA sequencing the gold standard for measuring genetic variation?


A) It is the easiest method of identifying genetic variation.
B) It uses mutations to detect differences in amino acid sequence.
C) It relies on proteins instead of genetic sequence.
D) It determines the exact genetic sequence, and thus the absolute variation in a population.
E) It is the least accurate, and is not the gold standard.

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Nonadaptive mechanisms of evolutionary change are:


A) migration (gene flow) , mutation, and genetic drift.
B) migration (gene flow) , balancing selection, and genetic drift.
C) migration (gene flow) , sexual selection, and genetic drift.
D) mutation, sexual selection, and genetic drift.
E) mutation, genetic drift, and heterozygote advantage.

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Like natural selection, genetic drift always leads to adaptations within populations; only mutations do not result in adaptations.

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Recall that in Mendel's garden peas, the yellow gene determines flower color, with the A (yellow) allele dominant to the a (green) allele. In a population of 200 plants, the genotype frequencies are 50% AA, 25% Aa, and 25% aa. What are the allele frequencies?


A) 50% A, 50% a
B) 50% A, 25% a
C) 87.5% A, 12.5% a
D) 62.5% A, 37.5% a
E) 75% A, 25% a

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What is the fundamental concept that causes gel electrophoresis of proteins to work?


A) Different proteins have different charges and sizes.
B) Different proteins respond in the same way to dyes in a gel.
C) Some proteins are enzymes and will react with molecules in the gel.
D) All proteins have the same charge and will move through the gel at the same speed.
E) All proteins will react with a dye to produce a band.

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Imagine the following genotype frequencies in a population: p2 = 0.49, 2pq = 0.42, q2 = 0.09. Now assume that there is nonrandom mating where individuals with one genotype will only mate with individuals that also have their genotype. Assume this pattern of mating goes on until the frequency of heterozygotes is effectively zero. What will the frequency of allele p be in the population?


A) 0) 3
B) 0) 7
C) 0) 91
D) 0) 49
E) 1) 0

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In a hypothetical population of 1000 frogs there exists a gene with two alleles. 280 of the frogs are homozygous dominant (DD) , and 220 are homozygous recessive (dd) . What is the frequency of heterozygotes in the population?


A) 0) 0
B) 0) 28
C) 0) 22
D) 0) 50

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Consider the following two populations and the frequencies of alleles at the FGFR-1 locus.  Allele 1  Allele 2  Allele 3  Allele 4  Population 1 0.250.250.250.25 Population 2 0.500.420.050.03\begin{array} { | l | l | l | l | l | } \hline & \text { Allele 1 } & \text { Allele 2 } & \text { Allele 3 } & \text { Allele 4 } \\\hline \text { Population 1 } & 0.25 & 0.25 & 0.25 & 0.25 \\\hline \text { Population 2 } & 0.50 & 0.42 & 0.05 & 0.03 \\\hline\end{array} Which of the populations has greater allelic variation?


A) population 1
B) population 2
C) Neither, allelic diversity is the same for both populations.

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All genes have the same rate of accumulation of genetic differences.

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A gene pool is comprised of what?


A) all the genes in a population
B) all the alleles within a population
C) all the individuals within a population
D) all the offspring within a population

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What is the hypothetical long-term result of different mutations accumulating in different populations?


A) the evolution of different species
B) the extinction of one population
C) merging the populations through migration
D) fixation of the same alleles in both populations
E) decreased genetic isolation

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Migration, genetic drift, and mutation are like natural selection in that they:


A) result in evolution of a population.
B) may alter the allele frequency in a population.
C) may alter the genotype frequency in a population.
D) are all methods of evolutionary change.
E) All of these choices are correct.

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How does gel electrophoresis allow researchers to observe genetic variation?


A) Gel electrophoresis enables a scientist to identify dominant and recessive traits.
B) Gel electrophoresis enables scientists to identify alleles that vary.
C) Gel electrophoresis enables scientists to replicate a strand of DNA.
D) Gel electrophoresis enables a scientist to link phenotype to genotype.
E) Protein gel electrophoresis enables a scientist to sequence DNA.

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Using protein gel electrophoresis to measure genetic variation in populations has some drawbacks. Which of the following is/are problems with the technique?


A) It can't detect synonymous mutations. That is, differences in DNA sequences that result in the same amino acid sequence can't be detected with this method.
B) It can't detect differences in noncoding DNA.
C) It can only be used with proteins that can be stained or otherwise labeled and visualized.
D) It can't detect mutations that do not affect the mobility of a protein within the gel, even if the protein's amino acid sequence is changed.
E) None of the answer options is correct.

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In contrast to positive and negative selection, _____ selection acts to maintain two or more alleles in a population.


A) balancing
B) disruptive
C) stabilizing
D) directional

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A population experiencing genetic drift will be in Hardy-Weinberg equilibrium.

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Dodos were flightless birds that have been extinct for about 300 years. Imagine that biologists found two surviving dodos on present-day Earth and mated this pair of birds. What would you expect of the resulting dodo population?


A) The maximum number of alleles present for any gene in the new population is two.
B) Certain neutral mutations in this dodo population could become fixed, given the small population size.
C) Adaptations will occur in this population as a result of genetic drift.
D) Due to a population bottleneck, the frequency of alleles in this new dodo population may be very different from the frequencies expected in larger (now nonexistent) populations.

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Which of the following statements is TRUE regarding natural populations?


A) Consistent with Thomas Malthus's hypothesis, most populations expand geometrically generation after generation.
B) Well-established populations are typically stable in size.
C) Resource availability generally plays no role in the size of a population.
D) All populations evolve rapidlytime is rarely a factor in evolution.

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